Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis.

Frontiers in Systems Neuroscience
Maria B Passani, Clara Ballerini

Abstract

Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the CNS whose pathogenesis remains largely unknown, and available therapies are rarely successful in reversing neurological deficits or stopping disease progression. Ongoing studies on MS and the widely used murine model of experimental autoimmune encephalomyelitis (EAE) are focused on the many components of this complex and heterogeneous neurodegenerative disease in the hope of providing a mechanism-based characterization of MS that will afford successful strategies to limit and repair the neuronal damage. Recently, histamine has been postulated to have a key regulatory role in EAE and MS pathogenesis. Histamine is a mediator of inflammation and immune responses, exerting its many actions through four G protein-coupled receptors (H(1,2,3,4)R) that signal through distinct intracellular pathways and have different therapeutic potentials as they vary in expression, isoform distribution, signaling properties, and function. Immune cells involved in MS/EAE, including dendritic cells (DCs) and T lymphocytes, express H(1)R, H(2)R and H(4)R, and histamine may have varying and counteracting effects on a particular cell type, depending on the receptor subtype...Continue Reading

Citations

Aug 2, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Anthony T Reder, Xuan Feng
Mar 16, 2013·British Journal of Pharmacology·K KarlstedtP Panula
Jul 15, 2015·Neuropharmacology·Gustavo ProvensiMaria Beatrice Passani
May 9, 2014·Frontiers in Systems Neuroscience·M Beatrice PassaniJian-Sheng Lin
May 13, 2014·Frontiers in Cellular Neuroscience·Sandra M RochaLiliana Bernardino
Jun 21, 2013·Nature Reviews. Neuroscience·Pertti Panula, Saara Nuutinen
Jan 4, 2019·Inflammopharmacology·Amal Megdad-LamraouiFatima Laraba-Djebari
Aug 27, 2019·Frontiers in Immunology·Mark R ZielinskiNoel R Rose
Apr 14, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Françoise MorinLuc Vallières

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