PMID: 7536702Jan 1, 1994Paper

Histamine and serotonin released from the rat perfused heart by compound 48/80 or by allergen challenge influence noradrenaline or acetylcholine exocytotic release

Fundamental & Clinical Pharmacology
H FuderP Schwarz

Abstract

Terminal nerve fibres of the autonomic nervous system closely approach mast cells in peripheral organs, and mutual influences between release of neurotransmitters or mast cell mediators may cause neuro-immunological interactions. We have studied the influence of mast cell degranulation on the release of endogenous noradrenaline and newly incorporated acetylcholine (such as 14C-choline/acetylcholine overflow) evoked by stimulation of extrinsic postganglionic sympathetic or preganglionic vagal nerves in the rat Langendorff heart perfused with Tyrode solution. Compound 48/80 perfused in normal hearts, or ovalbumin infused into hearts from rats sensitized to ovalbumin, enhanced the overflow of endogenous histamine and serotonin. Both stimuli increased the release of mediators to a similar extent and with fast kinetics. Maximum average concentrations in the perfusate of histamine were about 800 nmol/l, and of serotonin 40 nmol/l, in a sample collected within 4 min after mast cell degranulation. Stimulation of autonomic nerves did not affect basal histamine or serotonin overflow. Whereas basal overflows were unaffected, the stimulation-evoked releases of both noradrenaline and acetylcholine, were facilitated when compound 48/80 was p...Continue Reading

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Citations

Jul 2, 2009·Autonomic & Autacoid Pharmacology·S K WalshC L Wainwright
Apr 20, 2004·Journal of Cardiovascular Pharmacology and Therapeutics·Shizuko TakanoJunko Kimura
Jan 13, 2018·International Journal of Molecular Sciences·Scott P Levick, Alexander Widiapradja
Mar 26, 1998·Journal of Cardiovascular Pharmacology·R A HumphreysJ R Parratt

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