Histamine challenges discriminate between symptomatic and asymptomatic children. MAS-Study Group. Multicentre Allergy Study

The European Respiratory Journal
B NiggemannMAS-Study Group. Multicentre Allergy Study

Abstract

The aims of this study were to investigate a threshold value for bronchial responsiveness in children aged 7 yrs, which discriminates between symptomatic and asymptomatic children, and to identify determinants of this responsiveness. Titrated bronchial histamine challenges using the reservoir method were performed in 645 children aged 7 yrs, from the birth cohort Multicentre Allergy Study (MAS). When defining a reference population of healthy children within the MAS cohort, the 95th percentile of the provocative concentration causing a 20% fall in forced expired volume in one second PC20 among these asymptomatic study subjects amounted to 0.60 mg x mL(-1). This resulted in a specificity of 93.0% and a sensitivity of 45.9%, for discriminating between "current wheezers" and "non-current wheezers". Determinants of airway responsiveness at this age were pulmonary function, sensitization to indoor allergens, total immunoglobulin E and current wheeze. The results indicate that a very low cut-off provocative concentration causing a 20% fall in forced expired volume in one second (<1.0 mg x mL(-1)) defines airway hyperresponsiveness in children aged 7 yrs using the reservoir method. Provocation protocols for histamine challenges in thi...Continue Reading

Citations

Oct 12, 2002·Paediatric Respiratory Reviews·Susanne LauUNKNOWN MAS Group
Oct 12, 2002·Paediatric Respiratory Reviews·Renate NickelSusanne Lau
Jan 30, 2003·American Journal of Respiratory and Critical Care Medicine·Louis-Philippe Boulet
Sep 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R NickelUNKNOWN German Multicenter Allergy Study Group
Aug 29, 2006·Lancet·Sabina IlliUNKNOWN Multicentre Allergy Study (MAS) group
Mar 22, 2002·Respiratory Medicine·R J KurukulaaratchyS H Arshad
May 8, 2004·The Journal of Allergy and Clinical Immunology·Sabina IlliUNKNOWN Multicenter Allergy Study Group
Apr 1, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Dirk SchrammSusanne Lau
Mar 17, 2007·Allergy·M KabeschR Nickel
Mar 19, 2003·The Journal of Allergy and Clinical Immunology·Claudia SenglerRenate Nickel

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