Histamine Excites Rat GABAergic Ventral Pallidum Neurons via Co-activation of H1 and H2 Receptors

Neuroscience Bulletin
Miao-Jin JiJing-Ning Zhu

Abstract

The ventral pallidum (VP) is a crucial component of the limbic loop of the basal ganglia and participates in the regulation of reward, motivation, and emotion. Although the VP receives afferent inputs from the central histaminergic system, little is known about the effect of histamine on the VP and the underlying receptor mechanism. Here, we showed that histamine, a hypothalamic-derived neuromodulator, directly depolarized and excited the GABAergic VP neurons which comprise a major cell type in the VP and are responsible for encoding cues of incentive salience and reward hedonics. Both postsynaptic histamine H1 and H2 receptors were found to be expressed in the GABAergic VP neurons and co-mediate the excitatory effect of histamine. These results suggested that the central histaminergic system may actively participate in VP-mediated motivational and emotional behaviors via direct modulation of the GABAergic VP neurons. Our findings also have implications for the role of histamine and the central histaminergic system in psychiatric disorders.

References

Jan 1, 1989·Neuroscience·P PanulaM S Airaksinen
Jan 22, 1987·The Journal of Comparative Neurology·D S ZahmL Heimer
Jul 23, 1999·Annals of the New York Academy of Sciences·C P Bengtson, P B Osborne
Apr 29, 2000·Experimental Neurology·O V AnichtchikP Panula
Dec 19, 2002·The Journal of Clinical Investigation·Kazuhiko TakahashiHidehito Kotani
Feb 4, 2003·Nature Reviews. Neuroscience·Helmut Haas, Pertti Panula
Nov 16, 2004·Annals of the New York Academy of Sciences·Kentaro IwabuchiKazuhiko Yanai
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kyle S Smith, Kent C Berridge
May 2, 2006·The American Journal of Psychiatry·Jeffrey M MillerHerbert D Kleber
Mar 12, 2008·The European Journal of Neuroscience·A ZlomuzicaE Dere
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Jan 21, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M JutelC A Akdis
Jan 1, 2010·Advances in Experimental Medicine and Biology·Gerold BongersRob Leurs
Aug 31, 2012·Brain Structure & Function·Anushree TripathiElisa Mengual
Dec 21, 2012·Trends in Pharmacological Sciences·Roland SeifertArmin Buschauer
Jan 1, 2014·Cerebellum & Ataxias·Bin LiJian-Jun Wang
Aug 29, 2017·Current Biology : CB·Yi WangJing-Ning Zhu

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Citations

Oct 13, 2020·Frontiers in Cell and Developmental Biology·Rocío Valle-BautistaAnayansi Molina-Hernández
Oct 3, 2021·British Journal of Pharmacology·Lin YangZhong Chen

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