Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing Neurons via Postsynaptic H1 and H2 Receptors

Molecular Neurobiology
Qian-Xing ZhuangJing-Ning Zhu

Abstract

The central histaminergic nervous system, originating from the tuberomammillary nucleus (TMN) of the hypothalamus, widely innervates almost the whole brain, including the basal ganglia. Intriguingly, the histaminergic system is altered in parkinsonian patients. Yet, little is known about the effect and mechanisms of histamine on different types of neurons in the basal ganglia circuitry. Here, by using anterograde tracing, immunostaining, patch clamp recording, and single-cell qPCR techniques, we investigate the histaminergic afferents in the striatum, the major input structure of the basal ganglia, as well as the effect of histamine on the striatal GABAergic medium spiny projection neurons (MSNs). We report a direct histaminergic projection from the hypothalamic TMN to the striatum in rats. Furthermore, histamine exerts a strong postsynaptic excitatory effect on both dopamine D1 and D2 receptor-expressing MSNs. The concentration-response curves and the EC50 values for histamine on these two types of MSNs are similar. In addition, dopamine D1 and D2 receptor-expressing MSNs co-express histamine H1 and H2 receptor mRNAs. Both histamine H1 and H2 receptors are co-localized on dopamine D1 and D2 receptor-expressing MSNs and co-medi...Continue Reading

References

Sep 23, 1994·Science·A M GraybielM Kimura
Aug 22, 1997·Brain Research·C S Colwell, M S Levine
May 13, 1999·Nature Neuroscience·T Koós, J M Tepper
Apr 29, 2000·Experimental Neurology·O V AnichtchikP Panula
Feb 13, 2001·Progress in Neurobiology·R E BrownH L Haas
Feb 20, 2002·Neuroscience Letters·Tatiana M KorotkovaRitchie E Brown
Feb 4, 2003·Nature Reviews. Neuroscience·Helmut Haas, Pertti Panula
Jun 7, 2005·Trends in Neurosciences·Sten GrillnerMartin A Wikström
Mar 15, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Jordi Gomez-RamirezJonathan M Brotchie
May 23, 2006·Nature Reviews. Neuroscience·Henry H Yin, Barbara J Knowlton
Oct 4, 2006·Neuron·Thomas Wichmann, Mahlon R Delong
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Jul 24, 2010·British Journal of Pharmacology·J C McGrathC L Wainwright
Nov 26, 2010·Brain Pathology·Daniel J van WamelenDick F Swaab
Jan 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nao ChuhmaStephen Rayport
Feb 23, 2011·Neuron·Jun ZhangJian-Jun Wang
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tommas J EllenderJ Paul Bolam
Jun 21, 2013·Nature Reviews. Neuroscience·Pertti Panula, Saara Nuutinen
Aug 16, 2013·British Journal of Pharmacology·Paul L Chazot
Mar 19, 2014·Trends in Neurosciences·Bart A Ellenbroek, Bibinaz Ghiabi
Apr 25, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rhannan H WilliamsElda Arrigoni
Jul 30, 2014·Nature Neuroscience·Paolo CalabresiMassimiliano Di Filippo
Mar 19, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiamei LianChao Deng
Jun 19, 2015·Pharmacological Reviews·Pertti PanulaHelmut L Haas
Jun 24, 2015·Nature Reviews. Neurology·Ling ShanJerome M Siegel
Aug 16, 2015·Neuropharmacology·J Paul Bolam, Tommas J Ellender
May 14, 2017·Current Opinion in Neurobiology·Ada Eban-RothschildLuis de Lecea
Aug 29, 2017·Current Biology : CB·Yi WangJing-Ning Zhu

❮ Previous
Next ❯

Citations

Jun 20, 2019·Genes, Brain, and Behavior·Shamsiiat AbdurakhmanovaPertti Panula
May 21, 2019·Frontiers in Cellular Neuroscience·Guang-Ying LiJing-Ning Zhu
Jun 22, 2018·Frontiers in Endocrinology·Annunziatina LaurinoLaura Raimondi
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Rocío Valle-BautistaAnayansi Molina-Hernández
Oct 6, 2020·Biological Psychiatry·Kevin M ManzBrad A Grueter
Mar 18, 2021·PloS One·Edgardo Galan-Vasquez, Ernesto Perez-Rueda

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
PCR

Key Resources (RRID) Mentioned

AB_2277328
AB_2121375
AB_10718518
AB_2278725
AB_905382
AB_2094980

Software Mentioned

ASW
Real
FV10
ARRIVE
Time StatMiner
pClamp
Agilent ChemStation

Related Concepts

Related Feeds

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.