Jan 1, 1981

Histamine H1- and H2-receptors are differentially and spatially distributed in cerebral vessels

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
P M Gross

Abstract

Receptor sites for neurotransmitters may be spatially oriented within cerebral vascular walls. The direction from which neurohumoral stimuli arise (e.g., perivascular or intravascular) and the location and type of receptor activated may therefore determine the nature of vascular response. I review a series of studies that examined cerebrovascular responses to histamine and suggest that histamine receptors are differentially and spatially organized in two profiles within the cerebral circulation. A transmural distribution is suggested from the following results: increases in permeability of the blood-brain barrier (endothelial cells) to intra-arterial infusion of histamine were mediated by H2-receptors; increases in blood flow to intra-arterial infusion of histamine occurred only after the blood-brain barrier was disrupted and were the result of stimulation of both H1- and H2-receptors. These responses probably occur within inner layers of arterial smooth muscle; dilatation of pial arterioles to local microapplication of histamine and its receptor agonists indicates that H2-receptors are the predominant type in outer layers of arterial smooth muscle. A segmental profile of histamine receptors within the cerebrovascular bed is su...Continue Reading

Mentioned in this Paper

Muscle, Smooth, Vascular
Histamine Measurement
Blood - Brain Barrier Anatomy
Receptors, Histamine H1
Arterial System
Histamine H2 Receptors
Cerebrovascular System
Blood Vessel
Brain
Pathological Dilatation

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