Abstract
H1-antihistamine has been shown to be effective in treating patients with allergic rhinitis (AR), but its mechanism is still uncertain. We investigated effects of histamine H1 receptor (HRH1) gene polymorphisms on the efficacy of oral H1-antihistamine in perennial patients with AR caused by mites in the Chinese Han population for the first time. A total of 224 Han Chinese patients with AR and 165 Han Chinese healthy volunteers were selected. Genotype and allele frequency distribution of -17C/T in HRH1 gene in patients with AR, serum levels of eosinophil cationic protein (ECP), total immunoglobulin E (IgE), and specific IgE were detected. The clinical symptoms of patients with AR were evaluated with visual analogue scale (VAS). Direct counting method was applied to calculate genotype and allele frequencies. Higher levels of serum ECP and total IgE were shown in the AR group. Moreover, patients with CT, TT, or CT+TT genotype increased the risk of AR incidence in the in the -17C/T site of HRH1, and CC genotype and CT+TT genotype were associated with gender, asthma, VAS score, total IgE level, and specific IgE level in patients with AR. In addition, oral administration of H1-antihistamines improves clinical symptoms of patients wit...Continue Reading
References
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·S ZhuA J Sandford
Mar 17, 2001·Allergy·F MarcucciG Coniglio
May 8, 2001·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P IgazA Falus
Jul 9, 2003·The Journal of Allergy and Clinical Immunology·Cezmi A Akdis, Kurt Blaser
Jan 18, 2005·Biochemical Pharmacology·Masahiro MatsubaraKazuhide Hasegawa
Oct 27, 2006·Journal of Neural Transmission·S AnttilaT Lehtimäki
Nov 9, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jeong Joong KimJae Hoon Lee
Mar 17, 2007·Allergy·P J BousquetJ Bousquet
Oct 12, 2007·The Journal of Pharmacology and Experimental Therapeutics·Andrea StrasserRoland Seifert
Jan 4, 2008·Nature Reviews. Drug Discovery·Robin L ThurmondPaul J Dunford
Mar 26, 2008·Allergy·J BousquetUNKNOWN AllerGen
Sep 24, 2009·Allergy and Asthma Proceedings·Philip Lieberman
Mar 9, 2010·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Inês Cristina Camelo-Nunes, Dirceu Solé
Oct 29, 2011·Therapeutic Advances in Respiratory Disease·Tunis OzdoganogluHasan Mete Inancli
Nov 17, 2011·PloS One·Mei-Ping LuLei Cheng
Jan 10, 2012·Allergy and Asthma Proceedings·Michael S Blaiss
Feb 1, 2012·The Journal of International Medical Research·Y G JungS K Chung
Mar 16, 2012·The Journal of Allergy and Clinical Immunology·Warner CarrJean Bousquet
Nov 8, 2012·Mediators of Inflammation·Hideaki ShirasakiTetsuo Himi
Jun 8, 2013·Allergy·K KrauseM Maurer
Oct 30, 2013·Nature Reviews. Rheumatology·Jenny Buckland
Nov 19, 2013·Pharmacogenomics·Pedro AyusoElena García-Martín
Apr 26, 2016·Therapeutics and Clinical Risk Management·Xue Yan WangDe Yun Wang
Nov 27, 2016·International Forum of Allergy & Rhinology·Jian GuYou Li