PMID: 9437718Jan 1, 1997Paper

Histamine H1-receptors modulate somatostatin receptors coupled to the inhibition of adenylyl cyclase in the rat frontoparietal cortex

Peptides
L PueblaE Arilla

Abstract

Since exogenous histamine has been previously shown to increase the somatostatin (SS) receptor-effector system in the rat frontoparietal cortex and both histamine H1-receptor agonists and SS modulate higher nervous activity and have anticonvulsive properties, it was of interest to determine the participation of the H1-histaminergic system in this response. The intracerebroventricular (i.c.v.) administration of the specific histamine H1-receptor agonist 2-pyridylethylamine (PEA) (10 micrograms) to rats 2 h before decapitation increased the number of SS receptors (599 +/- 40 vs 401 +/- 31 femtomoles/mg protein, p < 0.01) and decreased their apparent affinity for SS (0.41 +/- 0.03 vs 0.26 +/- 0.02 nM, p < 0.01) in rat frontoparietal cortical membranes. No significant differences were seen for the basal and forskolin (FK)-stimulated adenylyl cyclase (AC) activities in the frontoparietal cortex of PEA-treated rats when compared to the control group. In the PEA group, however, the capacity of SS (10(-4) M) to inhibit basal and FK (10(-5) M)-stimulated AC activity in frontoparietal cortical membranes was significantly higher than in the control group (34 +/- 1% vs 20 +/- 2%, p < 0.001). The ability of low concentrations of the stable ...Continue Reading

References

Sep 1, 1975·Journal of Medicinal Chemistry·G J DurantM E Parsons
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V T TranS H Snyder
Jan 1, 1992·Journal of Neural Transmission. General Section·A GarlindR F Cowburn
Sep 1, 1992·Neuropeptides·B ColásJ P Prieto
Nov 1, 1991·Epilepsy Research·R ScherklH H Frey
Sep 1, 1991·Brain Research Bulletin·H WadaA Yamatodani
Sep 1, 1990·Metabolism: Clinical and Experimental·M F Beal
Feb 15, 1990·The Journal of Comparative Neurology·M S Airaksinen, P Panula
Jan 1, 1989·Canadian Journal of Physiology and Pharmacology·I M Mazurkiewicz-Kwilecki, S Nsonwah
Sep 1, 1985·Peptides·C SusiniA Ribet
Jan 1, 1986·Annual Review of Neuroscience·G D Prell, J P Green
Apr 16, 1986·European Journal of Pharmacology·E ClaroF Picatoste
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D van CalkerB Hamprecht
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C B Srikant, Y C Patel
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P PanulaE Costa

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