Jun 23, 1976

Histamine (H2) receptor-adenylate cyclase system in pig skin (epidermis)

Biochimica Et Biophysica Acta
K Iizuka HadachiV Levine


Histamine activated adenylate cyclase in pig skin (epidermal) slices, resulting in the accumulation of cyclic AMP. This effect was highly potentiated by the addition of cyclic AMP-phosphodiesterase inhibitors (theophylline, papaverine). A specific H2 receptor inhibitor (metiamide) inhibited the effect of histamine completely, while other antihistamines (diphenhydramine, acetophenazine, perphenazine, fluphenazine, promethazine) inhibited the effect of histamine to various lesser degrees. It has been shown that both epinephrine and prostaglandin E stimulate epidermal adenylate cyclase. Our data using specific blocking agents indicate that histamine, epinephrine and prostaglandin E2 act independently on the epidermal adenylate cyclase system.

Mentioned in this Paper

Receptors, Drug
Antihistamines, Classical
Cyclic AMP, (R)-Isomer
Family suidae
Dose-Response Relationship, Drug
Adenylate Cyclase

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