Abstract
We investigated the role played by histamine H3 receptors in the control of intestinal peristalsis, using two different in vitro preparations of guinea-pig ileum. (a) Ileal segments were perfused from the oral end, inducing peristaltic movements (emptying waves), due to the activation of intramural reflexes. Such peristaltic motility was measured as changes in the perfusion pressure during the emptying phase and the threshold pressure for triggering the emptying wave was determined. (b) Ileal segments were mounted horizontally and circular muscle contraction evoked by the ascending peristaltic reflex was triggered by caudal distension of the intestinal wall. In perfused ileal segments, specific agonists acting at histamine H3 receptors, ((R)-alpha-methylhistamine and immepip, 1 nmol-10 micromol/l), did not cause any change in the threshold pressure for triggering the peristaltic wave, or in the rise of the perfusion pressure during the emptying phase. Similarly, circular muscle contractions evoked by caudal distension of the wall were not affected by these histamine H3 receptor agonists up to 10 micromol/l. In the same conditions, a complete inhibition of peristaltic movements was elicited by agonists acting at alpha2-adrenocep...Continue Reading
References
Mar 1, 1992·British Journal of Pharmacology·S J Taylor, G J Kilpatrick
Jan 1, 1991·British Journal of Pharmacology·R LeursH Timmerman
Nov 12, 1991·European Journal of Pharmacology·X X LuoB H Sheng
Apr 1, 1990·Agents and Actions·J C SchwartzH Pollard
Jan 1, 1991·Life Sciences·E PoliG Bertaccini
Sep 21, 1990·European Journal of Pharmacology·G J Menkveld, H Timmerman
Nov 1, 1990·British Journal of Pharmacology·R W HewS J Hill
Oct 1, 1990·British Journal of Pharmacology·A De LucaH K Wong-Dusting
Aug 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·C A MaggiA Meli
May 1, 1989·Neuropeptides·H D AllescherM Classen
Feb 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·M CostaJ Bornstein
May 14, 1987·Nature·J M ArrangJ C Schwartz
Dec 11, 1983·Neuroscience Letters·R HåkansonF Sundler
Jul 1, 1995·Neuroscience·K NitaharaE S Vizi
Sep 1, 1993·General Pharmacology·E PoliG Bertaccini
Jan 14, 1994·European Journal of Pharmacology·N SuzukiY Gomi
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·R R RuffoloJ P Hieble
Feb 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·P Holzer, C A Maggi
Dec 1, 1993·British Journal of Pharmacology·B CostallB R Tuladhar
Feb 4, 1994·Journal of Medicinal Chemistry·R C VollingaH Timmerman
May 30, 1997·Annals of the New York Academy of Sciences·E PoliG Bertaccini
Dec 1, 1958·British Journal of Pharmacology and Chemotherapy·E BülbringO B Saxby
Citations
Mar 28, 2008·Purinergic Signalling·J C Bornstein
Oct 12, 2001·Journal of Physiology, Paris·E PoliG Coruzzi
Apr 13, 2000·Journal of Physiology, Paris·G BertacciniW Schunack
Mar 1, 2000·British Journal of Pharmacology·A A IzzoF Capasso
Dec 6, 2002·British Journal of Pharmacology·M BeggM E Parsons
Apr 30, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Byung Joo KimInsuk So