Histamine H3 receptors do not modulate reflex-evoked peristaltic motility in the isolated guinea-pig ileum

European Journal of Pharmacology
E Poli, C Pozzoli

Abstract

We investigated the role played by histamine H3 receptors in the control of intestinal peristalsis, using two different in vitro preparations of guinea-pig ileum. (a) Ileal segments were perfused from the oral end, inducing peristaltic movements (emptying waves), due to the activation of intramural reflexes. Such peristaltic motility was measured as changes in the perfusion pressure during the emptying phase and the threshold pressure for triggering the emptying wave was determined. (b) Ileal segments were mounted horizontally and circular muscle contraction evoked by the ascending peristaltic reflex was triggered by caudal distension of the intestinal wall. In perfused ileal segments, specific agonists acting at histamine H3 receptors, ((R)-alpha-methylhistamine and immepip, 1 nmol-10 micromol/l), did not cause any change in the threshold pressure for triggering the peristaltic wave, or in the rise of the perfusion pressure during the emptying phase. Similarly, circular muscle contractions evoked by caudal distension of the wall were not affected by these histamine H3 receptor agonists up to 10 micromol/l. In the same conditions, a complete inhibition of peristaltic movements was elicited by agonists acting at alpha2-adrenocep...Continue Reading

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Citations

Mar 28, 2008·Purinergic Signalling·J C Bornstein
Apr 13, 2000·Journal of Physiology, Paris·G BertacciniW Schunack
Mar 1, 2000·British Journal of Pharmacology·A A IzzoF Capasso
Apr 30, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Byung Joo KimInsuk So

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