Histamine, histamine H3 receptor, and alcohol use disorder.

British Journal of Pharmacology
Pertti Panula

Abstract

Alcohol use disorder is associated with several mental, physical, and social problems. Its treatment is difficult and often requires a combination of pharmacological and behavioural therapy. The brain histaminergic system, one of the wake-active systems that controls whole-brain activity, operates through three neuronal GPCRs. The histamine H3 receptor (Hrh3), which is expressed in many brain areas involved in alcohol drinking and alcohol reward, can be targeted with a number of drugs developed initially for cognitive disorders and/or disorders related to sleep, wakefulness, and alertness. In all rodent alcohol drinking models tested so far, H3 receptor antagonists have reduced alcohol drinking and alcohol-induced place preference and cue-induced alcohol reinstatement. Several H3 receptor antagonists tested and found to be safe for humans could be subjected to clinical tests to treat alcohol use disorder. Preference should be given to short-acting drugs to avoid the sleep problems associated with the wake-maintaining effects of the drugs. LINKED ARTICLES: This article is part of a themed section on New Uses for 21st Century. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.3/i...Continue Reading

References

Sep 1, 1991·The Journal of Comparative Neurology·H EricsonC Köhler
Jan 1, 1990·Neuroscience·P PanulaE Kotilainen
Jan 1, 1989·Neuroscience·P PanulaM S Airaksinen
Jul 15, 1988·The Journal of Comparative Neurology·N InagakiH Wada
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P PanulaE Costa
Mar 3, 1980·Life Sciences·H L AltshulerD A Feinhandler
Jan 1, 1993·Journal of Neural Transmission. General Section·E SchlickerM Göthert
Sep 3, 1998·European Journal of Pharmacology·M El-GhundiB F O'Dowd
Apr 29, 2000·Experimental Neurology·O V AnichtchikP Panula
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·M S Brodie, S B Appel
Sep 8, 2000·Neuroreport·S Cassar
Nov 9, 2000·The European Journal of Neuroscience·O V AnichtchikP Panula
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·C L CunninghamD K Grandy
Apr 9, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M LintunenP Panula
May 2, 2002·The European Journal of Neuroscience·C Y JinPertti Panula
Feb 4, 2003·Nature Reviews. Neuroscience·Helmut Haas, Pertti Panula
Oct 24, 2003·Alcoholism, Clinical and Experimental Research·William M DoyonRueben A Gonzales
Jun 15, 2004·Current Opinion in Neurobiology·Candice ContetKatia Befort
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah ThrelfellSusan A Greenfield
Feb 25, 2005·Behavioral Neuroscience·Anita J Bechtholt, Christopher L Cunningham
Jun 2, 2005·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G B FoxA A Hancock
Nov 5, 2005·Alcoholism, Clinical and Experimental Research·Peter W MarinelliChristina Gianoulakis
Apr 22, 2008·Alcoholism, Clinical and Experimental Research·Jonathan W TheileRichard A Morrisett
Feb 20, 2009·The Journal of Pharmacology and Experimental Therapeutics·Jonathan W TheileRichard A Morrisett
Jun 10, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Saara NuutinenPertti Panula
Sep 3, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria SundvikPertti Panula
May 16, 2012·Frontiers in Systems Neuroscience·Patrizio BlandinaMaria B Passani
Dec 12, 2012·The International Journal of Neuropsychopharmacology·Aurelija JucaiteSvante Nyberg
Jun 21, 2013·Nature Reviews. Neuroscience·Pertti Panula, Saara Nuutinen
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zhifeng ZhouDavid Goldman
Jan 25, 2014·The American Journal of Drug and Alcohol Abuse·Salla Vuoristo-MyllysHannu Alho

❮ Previous
Next ❯

Citations

Jan 30, 2020·British Journal of Pharmacology·Paul L Chazot, Ekaterini Tiligada
Oct 17, 2020·Journal of Psychopharmacology·Iñigo Pallardo-FernándezLuis F Alguacil
Jul 3, 2021·International Journal of Molecular Sciences·Bastian Schirmer, Detlef Neumann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alcohol Use Disorder

Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.

© 2022 Meta ULC. All rights reserved