Histamine improves rat rota-rod and balance beam performances through H(2) receptors in the cerebellar interpositus nucleus

Neuroscience
Y-N SongJ-J Wang

Abstract

Previous studies have revealed a direct histaminergic projection from the tuberomamillary nucleus of hypothalamus to the cerebellum and a postsynaptic excitatory effect of histamine on the cerebellar interpositus nucleus neurons via histamine H(2) receptors in vitro, indicating that the histaminergic afferent inputs of cerebellar nuclei may be involved in the cerebellar function of motor control. To test this hypothesis, in this study histaminergic agents were bilaterally microinjected into the cerebellar interpositus nucleus of intact adult male rats, and their effects on motor balance and coordination of the animals performing accelerating rota-rod treadmill and balance beam tasks were observed. The results showed that microinjection of histamine into the cerebellar interpositus nucleus remarkably increased the time that animals balanced steadily on the rota-rod and markedly shortened the duration of passage through the balance beam, whereas GABA significantly depressed motor performances of animals on the rota-rod and beam, and normal saline influenced neither. In addition, administration of selective histamine H(2) receptor antagonist ranitidine considerably decreased the animals' endurance time on rota-rod and noticeably i...Continue Reading

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Citations

Oct 23, 2013·Pflügers Archiv : European journal of physiology·Chang-Zheng ZhangJian-Jun Wang
Mar 22, 2014·Pflügers Archiv : European journal of physiology·Dae Yun SeoJin Han
Jun 24, 2010·Critical Reviews in Toxicology·Giuseppina GiusiMarcello Canonaco
Jan 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shivsharan B DhaddeS Badami
Sep 26, 2006·Journal of Neuroscience Research·Jing-Ning ZhuJian-Jun Wang
Aug 9, 2012·Toxicology Mechanisms and Methods·Pandian NagakannanVeeresh P Veerapur
May 8, 2015·Molecular Neurobiology·Chuen-Lin HuangNai-Kuei Huang
Feb 23, 2011·Neuron·Jun ZhangJian-Jun Wang
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Jan 1, 2014·Cerebellum & Ataxias·Bin LiJian-Jun Wang
Mar 16, 2021·Frontiers in Behavioral Neuroscience·Evelyn M Guilherme, Anna Carolyna L Gianlorenço
Sep 16, 2018·Neuroscience Letters·Evelyn M GuilhermeAnna C Gianlorenço
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ravi Chandra Sekhara Reddy DandugaVijaya Kishore Kanakaraju

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