Histamine in brain capillaries

Agents and Actions
F JoóZ Mezei

Abstract

A high amount of histamine was found in capillaries isolated by subcellular fractionation from the brain. In view of the important effects of histamine on vascular permeability in peripheral vessels, it was thought that histamine had a similar function in the cerebral vasculature. Intracarotic histamine infusion resulted in an enhanced pinocytosis of endothelial cells and te oedematous swelling of the astrocytic end-feet system. [3H]-Histamine, injected in the cerebral ventricles, accumulated in the capillary wall. Histamine and cimetidine activated hydroxyfatty acid and prostaglandin D2 synthesis in isolated brain capillaries. The possible function of the capillary histamine in the regulation of permeability of microvessels is discussed.

References

Sep 11, 1979·Life Sciences·J C Schwartz
Jan 1, 1975·Blood Vessels·T M El-Ackad, M J Brody
Sep 1, 1975·Analytical Biochemistry·H C KieferH S Kantor
Jun 1, 1966·Die Naturwissenschaften·H Lettré, N Paweletz
Mar 1, 1982·Prostaglandins·A GecseI Karnushina
Jan 1, 1953·Scandinavian Journal of Clinical and Laboratory Investigation·J GOA
Feb 1, 1965·Archives of Ophthalmology·N ASHTON, J G CUNHA-VAZ

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Citations

Apr 1, 1982·Agents and Actions·E DuxG Telegdy
Nov 3, 1994·European Journal of Pharmacology·A TósakiF Joó
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·G C Palmer
Nov 1, 1983·Neuroscience·N Halász, G M Shepherd
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·W A Fogel
Jun 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·C MaslinskiP Panula
Mar 30, 1999·European Journal of Pharmacology·B KisM A Deli
Mar 10, 2000·Journal of Chemical Neuroanatomy·P PanulaM Lintunen
Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K KarlstedtP Panula
Jun 30, 2000·Microvascular Research·F HernándezR E Catalán
Oct 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Hyslop, G De Nucci
May 1, 1987·Neuropathology and Applied Neurobiology·F Joó
May 10, 2002·Acta Physiologica Hungarica·B KisF Bari
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Jun 18, 2021·Journal of the Neurological Sciences·Paola Di MauroDavide Domenico Borzì

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