PMID: 9442829Jan 27, 1998Paper

Histamine-induced calcium released from cultured human mucosal microvascular endothelial cells from nasal inferior turbinate

Acta Oto-laryngologica
H IkedaT Yamashita

Abstract

Changes in cytosolic Ca2+ concentration ([Ca2+]i) in cultured human mucosal microvascular endothelial cells (HMMECs) from nasal inferior turbinate were measured using a fluorescent Ca(2+)-sensitive dye, fura-2, and photometric fluorescence microscopy. Histamine caused a transient increase in intracellular free Ca2+ in cell populations and in individual cells, followed by a decrease to a sustained elevation. Histamine (100 microM) elevated [Ca2+]i in HMMECs up to 563 +/- 20 nM from a resting level of 60 +/- 45 nM (means +/- SD, n = 31). Promethazine (a histamine H1 receptor antagonist) inhibited [Ca2+]i increase during histamine stimulation, whereas cimetidine (a H2 receptor antagonist) and thioperamide (a H3 receptor antagonist) showed no inhibition. These results suggest that the histamine increase [Ca2+]i in HMMECs induces both a Ca2+ release from stores and a Ca2+ influx through activation of the H1 receptor.

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Citations

Sep 8, 2012·Investigative Ophthalmology & Visual Science·Dayu LiDarlene A Dartt
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K C LeeC R Jan
Dec 22, 1999·The American Journal of Physiology·J H ParkJ S Alexander
Jul 18, 2003·Autonomic & Autacoid Pharmacology·C S Bockman, W Zeng

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