PMID: 7932796Apr 1, 1994Paper

Histamine-induced microvascular leakage in pial venules: differences between the SJL/J and BALB/c inbred strains of mice

Journal of Neurotrauma
T YongD S Linthicum

Abstract

The actions of histamine on pial venule leaky site formation were measured intravitally in two inbred strains of mice (BALB/c and SJL/J). Pial venules were visualized using a cranial window microscopy technique, and microvascular leaky site formation was assessed visually using a fluorescein-dextran indicator. SJL/J mice were found to be sensitive to histamine-induced leakage, whereas the BALB/c strain was refractory. Exposure to pertussis toxin enhanced the sensitivity to histamine in the SJL/J strain, but little effect was observed for BALB/c mice. However, the employment of a polymerase chain reaction (PCR) technique for the detection of mRNA for histamine H1 receptor identified receptor-specific message in isolated cerebrovascular endothelium from both strains of mice. The lack of pial responsiveness in the BALB/c mice remains unexplained. Mast cells in the dura mater were found to be more numerous in SJL/J mice than in BALB/c mice. This observation supports previous observations of strain-specific differences in CNS inflammation. The results support the concept that genetically controlled differences in vascular sensitivity and localization of CNS-associated mast cells may play important roles in the generation of vasogeni...Continue Reading

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Citations

Jul 9, 2013·Molecular Neurobiology·Damien P Kuffler
Jan 21, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Perttu Johannes LindsbergMarja-Liisa Karjalainen-Lindsberg
May 9, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Preet AnandNirmal Singh
Feb 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Blayne A SayedMelissa A Brown
Nov 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·David LominadzeSuresh C Tyagi
Jul 27, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kate Lykke LambertsenBente Finsen

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