Histamine-induced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factor-alpha

Microvascular Research
Y LiK N Dileepan

Abstract

In this study, we tested the synergy between histamine and LPS, and histamine and TNF-alpha, on endothelial cell production of interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1). Human coronary artery endothelial cells (HCAEC) were cultured in vitro with histamine (0.1 to 1000 microM) in the presence or absence of LPS or TNF-alpha for 24 h, and the secreted IL-6, IL-8 and MCP-1 were quantified. Unactivated HCAEC produced minimal levels of IL-6, IL-8, or MCP-1. The incubation of HCAEC with histamine resulted in low level induction of IL-6 and IL-8 production, which was dose-dependent and attained a plateau at a concentration of 10 microM. On the other hand, histamine failed to induce MCP-1 production. Stimulation of HCAEC with LPS or TNF-alpha caused dose-dependent increase in cytokine production. In the presence of all stimulatory concentrations of LPS and TNF-alpha tested, histamine was shown to further enhance IL-6 and IL-8 production. The effect of histamine on endothelial cell production of cytokines was completely inhibited by the H-1 receptor antagonist, diphenhydramine, and not by the H-2 antagonist, famotidine. Electrophoretic mobility shift assays of nuclear proteins extracted fr...Continue Reading

References

Feb 1, 1992·Biochemical Society Transactions·S J Hill
Oct 1, 1991·The Journal of Clinical Investigation·N A NelkenJ N Wilcox
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S Ylä-HerttualaD Steinberg
May 1, 1990·Molecular and Cellular Biology·T A Libermann, D Baltimore
Mar 1, 1990·The Journal of Experimental Medicine·J J MuléS A Rosenberg
Oct 31, 1985·The New England Journal of Medicine·M B FormanR Virmani
Jul 1, 1989·Cellular Immunology·M R ShalabyT Espevik
Oct 1, 1989·The Journal of Clinical Investigation·M BaggioliniS L Kunkel
Mar 1, 1988·The Journal of Experimental Medicine·M LotzD A Carson
Oct 1, 1981·The Journal of Allergy and Clinical Immunology·A P KaplanM Foster
Nov 1, 1994·Clinical and Experimental Immunology·Y DelnesteP Gosset
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Jan 1, 1993·Advances in Immunology·S AkiraT Kishimoto
Sep 1, 1996·Circulation·L M BiasucciA Maseri
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore
Jan 1, 1997·Annual Review of Immunology·M BaggioliniB Moser
Dec 14, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R ArnoldW König
May 11, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A B JehleK N Dileepan

❮ Previous
Next ❯

Citations

May 31, 2003·Mediators of Inflammation·Luqi ChiKottarappat N Dileepan
Mar 17, 2005·Mediators of Inflammation·Kottarappat N DileepanDaniel J Stechschulte
Sep 25, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Feng HaoMei-Zhen Cui
Jan 19, 2016·Frontiers in Immunology·Melissa Krystel-WhittemoreJohn G Wood
Jun 25, 2014·The British Journal of Dermatology·D Gutowska-OwsiakG S Ogg
Jun 21, 2006·Molecular Immunology·Chauncey J SpoonerRichard C Schwartz
Jul 17, 2004·Journal of Atherosclerosis and Thrombosis·Yasuyuki Sasaguri, Akihide Tanimoto
Jul 17, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Thanh-Sang Vo, Se-Kwon Kim
Jan 1, 2012·Case Reports in Cardiology·Sazzli KasimEugene McFadden
Feb 2, 2017·International Journal of Molecular Sciences·Barbara RizzacasaFrancesca Amati
Dec 1, 2017·International Journal of Molecular Sciences·Sean P Didion
Jul 18, 2002·Nature Reviews. Drug Discovery·Margaret A Cascieri
Sep 17, 2005·Neuroimmunomodulation·Ilia J ElenkovGeorge P Chrousos
Mar 22, 2019·Tissue Engineering. Part a·Tahereh DerakhshanHeather Gappa-Fahlenkamp
Jan 4, 2006·International Journal of Immunopathology and Pharmacology·D FioritiV Pietropaolo
Sep 13, 2017·Journal of Periodontology·David RibasJavier Monteseirín
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaoyu TanKottarappat N Dileepan
Jan 29, 2021·European Journal of Pharmacology·Valeria BurghiNatalia C Fernández
Mar 10, 2018·Journal of Periodontology·David RibasJavier Monteseirín
Mar 9, 2021·Restorative Dentistry & Endodontics·Roberto Alameda HoshinoPaulo Sérgio Cerri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.