PMID: 2905136Sep 1, 1988Paper

Histamine-induced regulation of IL-2 synthesis in man: characterization of two pathways of inhibition

Annales De L'Institut Pasteur. Immunology
R Huchet, D Grandjon


Histamine at molar concentrations ranging from 10(-5) to 10(-7) exerted an inhibitory effect upon IL-2 synthesis by peripheral blood mononuclear cells in normal man; two pathways of inhibition are described. The first pathway was found to alter the T4 lymphocytes which, in the system used in this study, synthesized nearly 90% of the total IL-2 production and had no suppressive activity. This suggests that histamine can act at the level of IL-2-producing cells. The second pathway of inhibition was related to induction of suppressor cells. Peripheral blood lymphocytes pre-incubated for 1 h with histamine 10(-5)-10(-7) M inhibited the IL-2 synthesis of normal autologous lymphocytes in a co-culture system. This activity was radio-resistant (1200 r) and mediated by T8 lymphocytes. These two pathways of inhibition were mediated by the specific interaction of histamine with H1- and H2-receptor-bearing mononuclear cells.


Mar 1, 1978·Cellular Immunology·S R Wang, B Zweiman
May 1, 1976·The Journal of Experimental Medicine·L ShouR A Good
Jan 1, 1981·Scandinavian Journal of Immunology·I LángG Petrányi
Apr 1, 1981·Cellular Immunology·Y ThomasD Granjon
Mar 1, 1982·The Journal of Experimental Medicine·R S Rappaport, G R Dodge

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May 1, 1990·Immunology Letters·T J HallJ Brostoff
Jun 1, 1993·American Journal of Respiratory Cell and Molecular Biology·B E HolT A Out

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