PMID: 6109256Nov 1, 1980Paper

Histamine-induced release of arachidonic acid and of prostaglandins in the peripheral vascular bed: mode of action

Naunyn-Schmiedeberg's Archives of Pharmacology
H Juan, W Sametz

Abstract

1. Injection or infusion of histamine intraarterially into the isolated perfused rabbit ear dose-dependently stimulated the release of prostaglandins (PGs) as measured by radioimmunoassay (PGE), bovine coronary artery strips (PGI2) and by the prelabeling technic with [1-14C]-arachidonic acid (PGI2, PGE2, PGF2 alpha, PGD2). 2. PG release was abolished by indometacin (1-3 microgram/ml) and reduced by the phospholipase A2 inhibitor quinacrine (10 microgram/ml) as well as by perfusing with calcium-free, 1 mM EGTA containing solution. 3. The histamine H2-receptor antagonists burimamide (5 microgram/ml) and cimetidine (2 microgram/ml) did not influence histamine-induced PG release. The H1-receptor antagonist mepyramine (0.1-1 microgram/ml) abolished histamine-induced mepyramine (0.1-1 microgram/ml) abolished histamine-induced PG release. 4. In the presence, but not in the absence, of bovine serum albumin there was a basal release of high amounts of arachidonic acid. Histamine tended to increase the released amount of radioactive arachidonic acid. In contrast to indometacin which only blocked PG release, mepyramine significantly reduced the histamine-stimulated release of arachidonic acid, too. 5. The results show that in the peripher...Continue Reading

References

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Citations

Jun 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·U Schwertschlag, E Hackenthal
Nov 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·H Juan, W Sametz
Apr 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, J Donnerer
May 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·H JuanF Lembeck
Jan 28, 1983·European Journal of Pharmacology·J Van de Voorde, I Leusen
Oct 1, 1984·European Journal of Pharmacology·A SchweizerM A Bray
May 17, 1991·European Journal of Pharmacology·P Schoeffter, T Godfraind
Jan 1, 1987·Journal of Steroid Biochemistry·R Garcia-Robles, L M Ruilope
Jul 1, 1992·Journal of the Autonomic Nervous System·A B Ebeigbe, M Cabanie
Dec 1, 1982·Prostaglandins, Leukotrienes, and Medicine·W Sametz, H Juan
Jul 1, 1985·Prostaglandins, Leukotrienes, and Medicine·H Juan, W Sametz
Apr 1, 1994·Journal of Ethnopharmacology·A Hiermann, F Bucar
Sep 9, 1999·European Journal of Pharmacology·W SametzR Wintersteiger
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E TraiffortJ C Schwartz
Jul 1, 1991·The Journal of Experimental Medicine·E VannierC A Dinarello
Jul 1, 1993·The Journal of Pharmacy and Pharmacology·M GwiltC G Henderson
Jan 1, 1992·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·M K KrstićS K Krstić
Feb 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H Behrendt, H G Kampffmeyer
Jun 1, 1986·Scandinavian Journal of Dental Research·A S JohanssonA C Granholm
Aug 2, 2008·International Immunopharmacology·Simone Campos Cavalher-MachadoMaria das Graças Müller de Oliveira Henriques
Nov 1, 1985·Acta Radiologica: Diagnosis·H Paajanen, P Uotila
Feb 1, 1988·The Journal of Pharmacy and Pharmacology·J Hardcastle, P T Hardcastle
Jun 26, 2002·Human Fertility : Journal of the British Fertility Society·Sandra J DowningHenry J Leese
Jan 1, 1989·Pharmacology & Toxicology·P Schoeffter, T Godfraind
Feb 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gregg R McCordChristopher T Minson
Mar 1, 1984·Current Eye Research·P S KulkarniB D Srinivasan
Nov 1, 1982·The American Journal of Physiology·A Hassid
Nov 1, 1981·Molecular and Cellular Endocrinology·M J Berridge

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