Histamine induces CD86 expression and chemokine production by human immature dendritic cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Gersende CaronPascale Jeannin

Abstract

Mast cells and immature dendritic cells (DC) are in close contact in peripheral tissues. Upon activation, mast cells release histamine, a mediator involved in the immediate hypersensitivity reaction. We therefore tested whether histamine could affect human DC activation and maturation. Histamine induces CD86 expression on immature DC in a dose-dependent (significant at 10(-7) M) and transient manner (maximal after 24-h stimulation). Histamine also transiently up-regulates the expression of the costimulatory and accessory molecules, CD40, CD49d, CD54, CD80, and MHC class II. As a consequence, immature DC exposed for 24 h to histamine stimulate memory T cells more efficiently than untreated DC. In addition, histamine induces a potent production of IL-6, IL-8, monocyte chemoattractant protein 1, and macrophage-inflammatory protein 1alpha by immature DC and also up-regulates IL-1beta, RANTES, and macrophage-inflammatory protein 1beta but not TNF-alpha and IL-12 mRNA expression. Histamine activates immature DC through both the H1 and H2 receptors. However, histamine-treated DC do not have a phenotype of fully mature cells, as they do neither show significant changes in the expression of the chemokine receptors, CCR5, CCR7 and CXC ch...Continue Reading

References

Jul 1, 1991·The Journal of Experimental Medicine·E VannierC A Dinarello
Mar 1, 1990·The Journal of Experimental Medicine·C R MackayL Dudler
Jul 11, 1985·The New England Journal of Medicine·R M NaclerioL M Lichtenstein
Feb 1, 1997·Current Opinion in Immunology·M CellaA Lanzavecchia
Nov 14, 1997·Physiological Reviews·D D MetcalfeY A Mekori
Apr 1, 1998·Nature·J Banchereau, R M Steinman
May 22, 1998·International Journal of Clinical & Laboratory Research·G MaroneM Triggiani
May 23, 1998·Annual Review of Immunology·R W DuttonS L Swain
Sep 12, 1998·Lancet·D Rudikoff, M Lebwohl
Oct 1, 1998·European Journal of Immunology·F SallustoA Lanzavecchia
Nov 20, 1998·The Journal of Clinical Investigation·T C van der Pouw KraanL A Aarden
Dec 16, 1998·Research in Immunology·A MantovaniS Sozzani
Feb 17, 1999·The Journal of Experimental Medicine·Y Banu, T Watanabe
Mar 9, 1999·The Journal of Allergy and Clinical Immunology·M White
Mar 9, 1999·The Journal of Allergy and Clinical Immunology·R Naclerio
Mar 17, 1999·Allergy and Asthma Proceedings·L B Bacharier, R S Geha
May 4, 1999·International Archives of Allergy and Immunology·O M Kon, A B Kay
Jun 4, 1999·Immunology Today·A Mantovani
Jun 8, 1999·European Journal of Immunology·F SallustoA Lanzavecchia
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K SatoT A Takahashi
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J SiroisE Y Bissonnette
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H KohkaT Akagi

❮ Previous
Next ❯

Citations

Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G CaronP Jeannin
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Tsicopoulos, Pde Nadai
Jul 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K BlümchenE Hamelmann
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dunia M JawdatJean S Marshall
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ralf GutzmerThomas Werfel
Sep 24, 2005·European Journal of Immunology·Kathrin HocheggerAlexander R Rosenkranz
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dunia M JawdatJean S Marshall
Dec 18, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P JohansenT M Kündig
May 26, 2010·Nature Reviews. Immunology·Soman N Abraham, Ashley L St John
Feb 9, 2010·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Wolfgang Bäumer, Kristine Rossbach
Dec 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathrin EllerAnna M Wolf
Nov 13, 2018·Frontiers in Immunology·Urban Švajger, Primož Rožman
Jun 26, 2002·The Journal of Dermatology·Masahiro Takigawa
Jan 5, 2002·Expert Opinion on Biological Therapy·Michael A MorseH Kim Lyerly
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra MazzoniDavid M Segal
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Isabelle CouillinBernhard Ryffel
Nov 19, 2004·The New England Journal of Medicine·F Estelle R Simons
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alison L Christy, Melissa A Brown
Apr 7, 2011·European Journal of Immunology·Pragnya Desai, Robin L Thurmond
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wojciech DawickiJean S Marshall
Jun 25, 2014·The British Journal of Dermatology·D Gutowska-OwsiakG S Ogg
Feb 3, 2016·Frontiers in Immunology·Cecilia Pessoa RodriguesJosé Alexandre Marzagão Barbuto
Nov 7, 2017·Immunity, Inflammation and Disease·Naoto YoshinoShigehiro Sato
Jun 20, 2018·American Journal of Reproductive Immunology : AJRI·Nicole Meyer, Ana Claudia Zenclussen
Jan 22, 2005·Nature Immunology·Stephen J GalliMindy Tsai
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra MazzoniDavid M Segal
Oct 30, 2007·The Journal of Clinical Investigation·Rajkumar NoubadeCory Teuscher
Jan 4, 2008·Nature Reviews. Drug Discovery·Robin L ThurmondPaul J Dunford
Jan 21, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M JutelC A Akdis
Apr 16, 2005·International Archives of Allergy and Immunology·Marek JutelCezmi A Akdis
Aug 5, 2004·Allergy·C A AkdisM Akdis
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·Arpita S BharadwajDevendra K Agrawal
Oct 30, 2008·Journal of Immunotoxicology·Alessandra GennariLaura Gribaldo
Aug 15, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·S SchumacherW Bäumer
Mar 28, 2013·Mediators of Inflammation·Sadaf Kasraie, Thomas Werfel
Aug 26, 2016·Immunopharmacology and Immunotoxicology·Heiko SchenkChristina Kloth
Sep 19, 2018·Mediators of Inflammation·Anna Cláudia Calvielli Castelo BrancoMaria Notomi Sato
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hajime SutoStephen J Galli
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul J DunfordRobin L Thurmond

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.