Histamine induces ovulation in the isolated perfused rat ovary

Journal of Reproduction and Fertility
G SchmidtN O Sjöberg

Abstract

Ovulatory effects of histamine and specific antagonists were studied in isolated perfused ovaries from immature rats treated with 10 i.u. PMSG to stimulate follicular growth and maturation. Histamine alone, like LH, induced ovulation in all ovaries tested, but the number of follicular ruptures was lower after histamine (7.0 and 2.2 ruptures, respectively, per ovary). The histamine-induced ovulations could be inhibited dose-dependently by the H1-receptor antagonist, pyrilamine, or the H2-antagonists, cimetidine and ranitidine. At the concentrations tested, these antagonists did not, when given separately, reduce the LH-induced ovulations significantly, but pyrilamine and cimetidine in combination lowered the ovulation frequency by 65%. The prostaglandin synthesis inhibitor, indomethacin, was not able to block the histamine-induced ovulations.

Citations

Jan 1, 1990·Reproductive Toxicology·I D Ionov
Oct 19, 2002·Journal of Reproductive Immunology·Mats Brännström, Anders Enskog
Dec 5, 1998·Zentralblatt für Veterinärmedizin. Reihe A·H Paczoska-Eliasiewicz, J Rzasa
Feb 1, 1988·Acta Physiologica Scandinavica·G SchmidtN O Sjöberg
Feb 2, 2011·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·S S Agrawal, M Alvin Jose
May 1, 1992·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·P BagavandossJ W Wilks
Aug 22, 2006·Biochemical and Biophysical Research Communications·Feng ZhangHong-Wen Deng
May 23, 2020·Animals : an Open Access Journal From MDPI·Pablo Fernández-HernándezBeatriz Macías-García

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