Histamine inhibits cell spreading and C3bi receptor clustering and diminishes hydrogen peroxide production by adherent human neutrophils

Journal of Cellular Physiology
J W FrancisH R Petty

Abstract

Cell adherence plays a central role in many host defense mechanisms. Human peripheral blood neutrophils possess cell surface receptors that contribute to cell adherence or detachment. Receptors specific for the C3bi cleavage fragment of the third component of complement (CR3) promote adhesion, whereas histamine receptors promote detachment. In the present study, we tested the ability of histamine to down-regulate the physiological effects of CR3 receptors. Histamine decreased the binding of 51Cr-labeled neutrophils to complement-coated surfaces (C3-coated surfaces) in a dose-dependent fashion. Scanning electron microscopic and optical microscopic observations of neutrophils on C3-coated surfaces revealed polarized or spherical cell morphologies in the absence or presence of histamine, respectively. Histamine inhibited the ability of CR3 to cluster on plasma membranes of neutrophils adherent to C3-coated surfaces as shown by fluorescence microscopy. In addition, histamine diminished but did not abolish the FMLP-stimulated increase in plasma membrane CR3 expression as measured by fluorometry. Histamine did not inhibit the release of marker proteins from specific or gelatinase containing granules by neutrophils in suspension. Hist...Continue Reading

References

Jun 1, 1979·The Journal of Clinical Investigation·J J HermanH R Colten
Oct 1, 1976·The Journal of Experimental Medicine·R S ZeigerH R Colten
Nov 1, 1985·The Journal of Clinical Investigation·G R RussA J d'Apice
Sep 1, 1989·Journal of Cellular Physiology·J W FrancisH R Petty
Dec 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·R BurdeG Schultz
Sep 1, 1987·The Journal of Cell Biology·P A DetmersZ A Cohn
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H R Petty, J W Francis
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S D WrightB W Erickson
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·F PatroneC Sacchetti
Nov 1, 1984·The Journal of Clinical Investigation·M BergerM M Frank
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S D WrightS C Silverstein
Oct 1, 1983·The Journal of Experimental Medicine·K IidaV Nussenzweig
Jan 1, 1984·Advances in Immunology·D J BeerR E Rocklin
Mar 25, 1982·The New England Journal of Medicine·M A ArnaoutH R Colten
Sep 1, 1982·The Journal of Clinical Investigation·B DewaldM Baggiolini
Jan 1, 1984·The Journal of Clinical Investigation·N DanaM A Arnaout
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H R PettyH M McConnell
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·F Sanchez-MadridT A Springer
Aug 12, 1982·The New England Journal of Medicine·L A BoxerR L Baehner
Oct 1, 1982·The Journal of Experimental Medicine·D I BellerR D Schreiber
Apr 1, 1980·The Journal of Clinical Investigation·C W Smith, J C Hollers

❮ Previous
Next ❯

Citations

Jan 1, 1996·General Pharmacology·J F KlinkerR Seifert
Feb 8, 2003·Experimental Eye Research·Victor M ElnerHoward R Petty
Aug 30, 2003·International Immunopharmacology·Jun HurJong-Young Kwak
May 26, 2007·Scandinavian Journal of Immunology·M AdlesicA Tarkowski
Mar 5, 2004·The Journal of Pharmacology and Experimental Therapeutics·Keisuke TakeshitaFlorian Gantner
Mar 20, 2010·Clinical and Vaccine Immunology : CVI·Wen-Lin SuJenn-Han Chen
Jul 3, 2002·Clinical and Diagnostic Laboratory Immunology·Patricia Méndez-SamperioJanet Palma
Nov 5, 2002·Clinical and Diagnostic Laboratory Immunology·Kunihiko KitagakiJoel N Kline
Apr 15, 2006·Clinical Microbiology Reviews·Deirdre ChurchRobert Lindsay
Sep 24, 2005·Infection and Immunity·R William DepaoloWilliam J Karpus
Oct 1, 2008·Infection and Immunity·Charles R BrownWilliam J Mitchell
Jun 25, 2008·Infection and Immunity·María de la Cruz Domínguez-PunaroMarcelo Gottschalk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.