Histamine: its novel role as an endogenous regulator of Con A-dependent T cell proliferation

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
H NakaneK Nakano

Abstract

The roles of histamine formed by the macrophage - T lymphocyte system were evaluated in the regulation of lymphocyte proliferation using mice lacking histamine receptors. Mice deficient in histamine type 1 (H1R), type 2 (H2R) or both receptors were employed to estimate possible intervention of the receptors in the histamine-dependent lymphocyte proliferation. Histamine was produced de novo by spleen cells. Con A-dependent T cell proliferation decreased when histamine produced in the culture was degraded by the addition of histaminase. The H2R-deficient mice also showed a significant decrease in the Con A-dependent T cell proliferation, whereas it was not modulated in the H1R-deleted mice. Consistent with the reduction in T cell proliferation, there was a significant down-regulation of the production of IL-2, a T cell growth factor, in the H2R-deficient mice. Con A-dependent IL-2 synthesis was abrogated by the addition of histaminase. Con A-dependent T cell proliferation is (up)regulated by histamine produced de novo through the H2R, suggesting that histamine is a newly found regulator of T cell proliferation.

Citations

May 9, 2006·The Journal of Clinical Investigation·Paul J BryceHans C Oettgen
May 20, 2015·Allergologia et immunopathologia·A DaschnerC Cuéllar
Dec 18, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P JohansenT M Kündig
Jan 4, 2008·Nature Reviews. Drug Discovery·Robin L ThurmondPaul J Dunford
Jul 18, 2012·Bulletin of Experimental Biology and Medicine·G I Lobov, M N Pan'kova

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