Jul 1, 1977

Histamine levels in the blood of humans experimental animals under normal conditions and following vaccination

Zhurnal mikrobiologii, epidemiologii, i immunobiologii
O A Vasil'evaN Kh Stavitskaia

Abstract

The authors present the results of study of the blood histamine content in intact rabbits and in the animals to which commercial vaccines with a different degree of reactogenic property for man were administered. The blood histamine level was also studied in practically healthy individuals and in those vaccinated with inactivated tick-borne encephalitis vaccine. The blood histamine content varied in intact rabbits from 4 to 10 microgram/ml, averaging 6.4 +/- 0.09 microgram/ml. Animal immunization caused elevation of the blood histamine content correlating with the reactogenic properties of the preparations for man: vaccines with low reactogenic properties--inactivated encephalitis and live measles vaccine produced no significant changes in the index under study; as to the typhoid vaccine with sextatoxoid, and smallpox vaccine with marked reactogenic properties--they stimulated significant histaminemia in rabbits. Revaccination of man against tick-borne encephalitis with the inactivated cultural vaccine caused an increase in the blood histamine content.

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Mentioned in this Paper

Histamine Measurement
Pertussis
Vaccines
Tick-borne encephalitis vaccine
Vaccination
Chinchilla<genus>
Smallpox
Immunization Domain
Encephalitis
Typhoid Fever

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