Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats

Experimental Physiology
Ph LesclousJ L Saffar

Abstract

Short-term studies have shown that histamine is involved, via its H2 receptors (H2R), in the mediator network regulating trabecular bone loss in long bones of ovariectomized (OVX) rats. It is not known whether this effect of histamine persists over time or involves other skeletal sites. In this study, rats were maintained for 6 months postOVX and treated daily with saline or famotidine (10 mg kg(-1)), an H2R antagonist. At the end of the experimental period, femur trabecular bone mass was markedly decreased in OVX rats, whether or not they were treated with famotidine. In contrast, in the fourth lumbar vertebra, where bone loss starts later than in the femur, famotidine treatment attenuated the decline in trabecular bone volume, protected the trabecular architecture, maintained the thickness of the cortices and reduced the numbers of osteoclasts and tartrate-resistant acid phosphatase-positive preosteoclasts, whereas it had no influence on bone formation parameters. In vertebral bone marrow of OVX rats, the numbers of mast cells (MCs) and non-MC histamine-producing cells increased, while famotidine treatment significantly diminished both cell populations. These data show that H2R antagonism does not protect trabecular bone mass...Continue Reading

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Citations

Nov 29, 2013·Journal of Periodontology·Renata LonghiniPaulo Sérgio Cerri
Jun 7, 2014·Pharmacological Reports : PR·Joanna FolwarcznaAnna Brzęczek
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Mar 3, 2020·Frontiers in Immunology·Deniz RagipogluVerena Fischer

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