PMID: 9185084Jun 1, 1997Paper

Histamine mediates the muscle layer-specific responses in the isolated swine myometrium

Journal of Veterinary Pharmacology and Therapeutics
T KitazawaTetsuro Taneike

Abstract

To clarify the role of histamine in uterine contractility, the effect of this biogenic amine on the myometrium of cyclic mature gilts was investigated by an isometric tension recording study in vitro. In addition, using crude membrane preparations isolated from the longitudinal (LM) and circular muscle (CM), the distribution of H1 histamine receptors was characterized by 3H-pyrilamine binding assay. Histamine caused a tetrodotoxin-resistant contractile response of LM and CM in Krebs solution, but LM (-logEC50 = 6.34) was more sensitive than CM (-logEC50 = 5.4). Pyrilamine decreased the excitatory response of histamine in both muscle layers. In pyrilamine-treated LM, a high concentration of histamine (1-30 microM) caused a slight inhibition of spontaneous contraction, and this inhibition was abolished by ranitidine. On the other hand, histamine did not cause any inhibition in the pyrilamine-treated CM preparations. Dimaprit (10-300 microM) concentration-dependently inhibited the spontaneous contraction of LM but not of CM. In the presence of pyrilamine and ranitidine, N alpha-methylhistamine, even at 10 microM, did not affect the spontaneous and electrical field stimulation (5Hz)-induced contraction of LM and CM layers. Specific...Continue Reading

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Citations

Jun 5, 2003·European Journal of Pharmacology·Takio KitazawaTetsuro Taneike
Nov 1, 2001·Journal of Pharmacological and Toxicological Methods·D J Crankshaw
Mar 24, 2016·Acta Veterinaria Scandinavica·Włodzimierz MarkiewiczJerzy Jan Jaroszewski
Aug 31, 1999·Journal of Autonomic Pharmacology·T KitazawaT Taneike

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