PMID: 9187264Jun 1, 1997Paper

Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937

Molecular Pharmacology
C ShayoA Baldi

Abstract

We examined the effects of histamine and its agonists on the expression of the c-fos and c-myc proto-oncogenes at the transcriptional and translational levels in the human promonocytic U937 cell line. Histamine transiently increased cAMP and c-fos expression through H2 receptors. Dibutyryl cAMP also increased c-fos mRNA and protein, and levels remained elevated even after 12 hr of treatment. Dose-dependence studies using histamine and dimaprit showed that the EC50 values for cAMP production and c-fos increase were similar, suggesting that cAMP might be involved in c-fos induction via H2 receptors. Furthermore, studies carried out using H7, a protein kinase A/protein kinase C inhibitor, blocked c-fos induction, whereas no effect was observed with bisindolylmaleimide, a specific protein kinase C inhibitor. No modification of c-myc expression could be detected on treatment with histamine or its analogues. Nevertheless, dibutyryl cAMP induced a down-regulation of the levels of this proto-oncogene. In addition, dibutyryl cAMP inhibited cell growth in a dose-dependent manner, whereas histamine failed to affect proliferation and differentiation of U937 cells. Cells pretreated with dimaprit showed a decrease in the cAMP response to sub...Continue Reading

References

May 15, 1976·International Journal of Cancer. Journal International Du Cancer·C Sundström, K Nilsson
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E TraiffortJ C Schwartz
Jan 1, 1992·Annual Review of Biochemistry·K B MarcuA J Patel
Feb 14, 1991·Nature·N P Gerard, C Gerard
Jan 1, 1991·Annual Review of Biochemistry·H R Herschman
Jan 1, 1991·Advances in Cancer Research·C A Spencer, M Groudine
Nov 4, 1988·Cell·T Curran, B R Franza
Jun 1, 1995·Pharmacology & Therapeutics·R LeursH Timmerman
Dec 15, 1994·European Journal of Pharmacology·M J SmitH Timmerman
Jan 6, 1995·Biochemical Pharmacology·F J BurczynskiM Hnatowich
Apr 15, 1993·The Biochemical Journal·H Hug, T F Sarre
Apr 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C DavioE Rivera
May 29, 2013·Molecular Systems Biology·Mathieu CourcellesPierre Thibault

❮ Previous
Next ❯

Citations

May 6, 2006·Molecular Pharmacology·Dong-Chan KimKyong-Tai Kim
Dec 29, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Naresha SaligramaCory Teuscher
May 30, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Ajoy Kumar Ghosh
Apr 26, 2020·The FEBS Journal·Angela Rodríguez GonzálezCarina Shayo
Jul 2, 2009·The Journal of Pharmacology and Experimental Therapeutics·Hidenori WakeMasahiro Nishibori
Jul 8, 2015·The Journal of Pharmacology and Experimental Therapeutics·Jiagen WenWei Zhang
May 26, 2006·Molecular Pharmacology·Hideo Kohka TakahashiMasahiro Nishibori
Sep 5, 2002·British Journal of Pharmacology·Giuseppina MoriniWalter Schunack
Jul 31, 1998·European Journal of Pharmacology·A BrodskyE Rivera
Jun 3, 1999·Biochemical Pharmacology·M A MedinaF Sánchez-Jiménez
Jan 27, 2004·Biochemical and Biophysical Research Communications·Carina ShayoCarlos Davio
Aug 20, 2003·The Journal of Investigative Dermatology·Naoko Kanda, Shinichi Watanabe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Pharmacology and Experimental Therapeutics
D G SawutzC L Johnson
The Journal of Immunology : Official Journal of the American Association of Immunologists
E MuñozB T Huber
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
R OkazakiT Matsumoto
© 2021 Meta ULC. All rights reserved