Histamine receptors and COVID-19.

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Madeleine Ennis, Katerina Tiligada

Abstract

Reports that the over-the-counter histamine H2 receptor antagonist famotidine could help treat the novel coronavirus disease (COVID-19) appeared from April 2020. We, therefore, examined reports on interactions between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and histamine receptor antagonists. A systematic literature search was performed by 19 September 2020, and updated on 28 October 2020, in PubMed, Scopus, Cochrane Library and Google Scholar using (COVID-19 OR coronavirus OR SARS-CoV-2) AND (histamine antagonist OR famotidine OR cimetidine). ClinicalTrials.gov was searched for COVID-19 and (famotidine or histamine). Famotidine may be a useful addition in COVID-19 treatment, but the results from prospective randomized trials are as yet awaited. Bioinformatics/drug repurposing studies indicated that, among several medicines, H1 and H2 receptor antagonists may interact with key viral enzymes. However, in vitro studies have to date failed to show a direct inhibition of famotidine on SARS-CoV-2 replication. Clinical research into the potential benefits of H2 receptor antagonists in managing COVID-19 inflammation began from a simple observation and now is being tested in multi-centre clinical trials. The positi...Continue Reading

References

Jun 15, 1991·Annals of Internal Medicine·T G Cantú, J S Korek
Jul 27, 1973·Nature·L M Lichtenstein, E Gillespie
Jul 1, 1982·Agents and Actions·T J Rising, S Lewis
Nov 20, 1998·The Journal of Clinical Investigation·T C van der Pouw KraanL A Aarden
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S KunzmannC B Schmidt-Weber
Nov 13, 2008·The Journal of Experimental Medicine·Flurina MeilerMübeccel Akdis
Aug 10, 2011·The Journal of Allergy and Clinical Immunology·Liam O'MahonyCezmi A Akdis
May 6, 2015·European Journal of Pharmacology·Gianni MaroneFrancescopaolo Granata
Nov 3, 2016·Journal of Innate Immunity·Liliana Portales-CervantesJean S Marshall
Mar 24, 2017·Handbook of Experimental Pharmacology·Francesco BorrielloGianni Marone
Feb 20, 2018·The Journal of Allergy and Clinical Immunology·Ana OliveraDean D Metcalfe
Oct 21, 2018·British Journal of Pharmacology·Ekaterini Tiligada, Madeleine Ennis
Feb 26, 2019·International Immunopharmacology·Abdollah JafarzadehZuhair Mohammad Hassan
Apr 27, 2019·Frontiers in Pharmacology·Paul L ChazotStephen Bonner
May 16, 2019·Journal of Pharmaceutical Health Care and Sciences·Miho YamasakiYorinobu Maeda
Sep 5, 2019·International Journal of Molecular Sciences·Jean S MarshallEdwin Leong
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Apr 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiangqi LiMingjun Gu
May 6, 2020·Antimicrobial Agents and Chemotherapy·Sangeun JeonSeungtaek Kim
May 7, 2020·JMIR Public Health and Surveillance·Moshe RogosnitzkyAlejandro R Jadad
May 18, 2020·Nature Medicine·Leah Shaffer
May 20, 2020·The FEBS Journal·Oleg O Glebov
Jun 9, 2020·BioRxiv : the Preprint Server for Biology·Laura RivaSumit K Chanda
Jun 11, 2020·Journal of Clinical Medicine·Jacek BajRyszard Maciejewski
Jun 25, 2020·Journal of Biomolecular Structure & Dynamics·Parth Sarthi Sen GuptaMalay Kumar Rana
Jul 24, 2020·Research Square·Robert W MaloneDarrell O Ricke
Aug 12, 2020·Reviews in Medical Virology·Coralie ValleEtienne Decroly

❮ Previous
Next ❯

Citations

Apr 4, 2021·Children·Piero ValentiniDanilo Buonsenso
Jun 4, 2021·Journal of Medicinal Chemistry·Thanigaimalai Pillaiyar, Stefan Laufer
Jun 3, 2021·International Journal of Molecular Sciences·Changbo QuYihang Pan
Jul 16, 2021·Signal Transduction and Targeted Therapy·Cameron MuraRobert Preissner
Aug 31, 2021·Frontiers in Pharmacology·Cameron MuraPhilip E Bourne

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT04389567
NCT04370262
NCT04504240
NCT04545008

Software Mentioned

PL pro

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.