Histamine receptors in mammalian retinas

The Journal of Comparative Neurology
Matthew J GastingerDavid W Marshak

Abstract

Mammalian retinas are innervated by histaminergic axons that originate from perikarya in the posterior hypothalamus. To identify the targets of these retinopetal axons, we localized histamine receptors (HR) in monkey and rat retinas by light and electron microscopy. In monkeys, puncta containing HR3 were found at the tips of ON-bipolar cell dendrites in cone pedicles and rod spherules, closer to the photoreceptors than the other neurotransmitter receptors. This is the first ultrastructural localization of any histamine receptor and the first direct evidence that HR3 is present on postsynaptic membranes in the central nervous system. In rat retinas, most HR1 were localized to dopaminergic amacrine cells. The differences in histamine receptor localization may reflect the differences in the activity patterns of the two species.

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Citations

Aug 8, 2014·Neuroscience and Biobehavioral Reviews·Erich H SchneiderRoland Seifert
Jul 10, 2012·Progress in Retinal and Eye Research·D I Flitcroft
Jul 30, 2011·The Journal of Comparative Neurology·Alejandro VilaDavid W Marshak
May 27, 2015·The Journal of Comparative Neurology·Anahit HovhannisyanThomas A Münch
Dec 30, 2014·PloS One·Ursula GreferathErica L Fletcher
Jan 12, 2017·The Journal of Comparative Neurology·Anita Hendrickson, Chi Zhang
Jan 18, 2011·Endocrinology·Melanie B HenryJoyce J Hwa
Aug 1, 2006·Current Eye Research·Matthew J GastingerDavid W Marshak
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Apr 24, 2015·Journal of Neurophysiology·Chikako GembaTomio Inoue
Dec 30, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Gonzalo OrtizRadouil T Tzekov
Aug 30, 2017·Cellular and Molecular Neurobiology·Kayo HorioEi-Ichi Miyachi
Sep 7, 2021·Frontiers in Behavioral Neuroscience·Eric ArsenaultBenoit Labonté

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