PMID: 1201376Oct 1, 1975Paper

Histamine receptors in peripheral vascular beds in the cat

British Journal of Pharmacology
S B Flynn, D A Owen

Abstract

1. The vasodilator activity of histamine has been studied in anaesthetized cats. 2. Histamine causes dose-dependent vasodilatation in the vasculature of the hind-limb and mesentery, perfused with blood at constant flow. 3. Experiments using the selective antagonists mepyramine and metiamide indicate the involvement of both H1- and H2-receptors in the vasodilator responses to histamine. Mepyramine (2.5 X 10(-6) mol/kg), causes displacement of the histamine dose-response curve. This displacement is maximum with a dose-ratio of about 10. Further dose-dependent displacement of the dose-response curve occurred after metiamide (4 X 10(-7) mol kg-1 min-1 and 2 X 10(-6) mol kg-1 min-1), although these doses of metiamide had no effect on histamine responses in the absence of mepyramine. 4. Vasodilator responses could also be elicited by the selective H1-receptor agonists, 2-methylhistamine, 2-(2-aminoethyl)pyridine and 2-(2-aminoethyl)thiazole and the selective H2-receptor agonist, 4-methylhistamine. 5. The selectivity of mepyramine and metiamide as histamine receptor antagonists was confirmed by their failure to reduce the vasodilator responses to acetylcholine, isoprenaline and bradykinin.

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Citations

Nov 1, 1984·Pflügers Archiv : European journal of physiology·N J RothwellM G Wyllie
Sep 1, 1983·Pflügers Archiv : European journal of physiology·H Suzuki, K Kou
May 1, 1981·Digestive Diseases and Sciences·K M WalusE D Jacobson
Dec 1, 1979·Agents and Actions·B I HirschowitzA L Waldo
Apr 1, 1981·Agents and Actions·D A OwenE H Quinn
Sep 1, 1977·European Journal of Pharmacology·A TuckerJ T Reeves
Aug 15, 1977·European Journal of Pharmacology·B M Johnston, D A Owen
Aug 15, 1979·European Journal of Pharmacology·B Dénes, K Greeff
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Aug 5, 1983·European Journal of Pharmacology·M TakedaH Maeno
Jun 3, 1983·European Journal of Pharmacology·M ImpicciatoreF Bordi
Jan 1, 1977·General Pharmacology·D A Owen
Jun 18, 1997·European Journal of Pharmacology·S Chiba, M Tsukada
Mar 20, 1980·The New England Journal of Medicine·A I JacobJ J Bourgoignie
Mar 1, 1981·Clinical and Experimental Pharmacology & Physiology·G D LordJ W Lance
Sep 1, 1977·British Journal of Pharmacology·S B FlynnD A Owen
Sep 1, 1979·The Journal of Pharmacy and Pharmacology·D A OwenR W Gristwood
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·P E Hicks
Mar 16, 2013·British Journal of Clinical Pharmacology·Euan A SandilandsDavid J Webb
Aug 1, 1979·The Journal of Surgical Research·T A MillerE D Jacobson
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Feb 1, 1984·Acta Pharmacologica Et Toxicologica·E MikkelsenL T Jespersen

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