PMID: 626Nov 3, 1975

Histamine receptors in the vasculature of the rabbit ear

Naunyn-Schmiedeberg's Archives of Pharmacology
Z S Ercan, R K Türker

Abstract

Histamine has a dual action on the isolated perfused ear preparation of the rabbit. The amine induced a dose-dependent rise in perfusion pressure when the preparation was perfused with Krebs' solution. This pressor response was reversed to a depressor effect when meypramine was added to the perfusion fluid. This depressor effect of the amine was also dose-related. Metiamide competitively inhibited the depressor effect of histamine. Prior treatment of the ear vessels with metiamide alone caused an increase in histamine-induced perfusion pressure. From these results it was concluded that the predominant pressor effect of histamine on the vascular bed of the rabbit ear is mediated through the H1-receptors and the depressor effect of the amine through histamine H2-receptors.

References

Oct 1, 1973·Agents and Actions·J W BlackJ H Wyllie
Oct 1, 1973·British Journal of Pharmacology·P S Goadby, E A Phillip
Jun 1, 1974·The Australian Journal of Experimental Biology and Medical Science·P R CarrollN Latt
Oct 1, 1965·The Australian Journal of Experimental Biology and Medical Science·I S De la Lande, M J Rand
Apr 21, 1972·Nature·J W BlackE M Parsons
Jun 1, 1972·British Journal of Pharmacology·D T Okpako
Jul 1, 1974·European Journal of Pharmacology·Z S ErcanR K Türker
Sep 1, 1947·British Journal of Pharmacology and Chemotherapy·H O SCHILD

Citations

Aug 1, 1980·Pflügers Archiv : European journal of physiology·R Casteels, H Suzuki
Sep 1, 1983·Pflügers Archiv : European journal of physiology·H Suzuki, K Kou
Jan 15, 1976·Experientia·Z S Ercan, R K Türker
Jan 1, 1977·General Pharmacology·D A Owen
Mar 1, 1982·Clinical and Experimental Pharmacology & Physiology·M J Stevens, R F Moulds
Feb 1, 1989·British Journal of Clinical Pharmacology·A OttossonL Edvinsson
Sep 1, 1981·British Journal of Pharmacology·M KonishiM Yamamoto
Jan 1, 1989·Pharmacology & Toxicology·P Schoeffter, T Godfraind

Related Concepts

Acetilcolina Cusi
Angiotensin II, Val(5)-
Metazoa
Arteries
Ear Structure
Ceplene
Antihistamines, Classical
Metiamide Monohydrochloride
Inotropism
Norepinephrine, (+, -)-Isomer

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