PMID: 3485790Feb 1, 1986

Histamine reduces Cl- activity in surface epithelial cells of frog gastric mucosa. Suggestive evidence for ionic coupling between surface epithelial and oxyntic cells

Pflügers Archiv : European journal of physiology
S CurciE Frömter


Intracellular chloride activity (acCl) and serosal as well as mucosal membrane potentials (Vcs and Vcm) were recorded in surface epithelial cells (SEC) of frog gastric mucosa during the resting state (cimetidine, 10(-4) mol/l) or during stimulation with histamine (10(-4) mol/l). Stimulation leads to a fall in acCl from 18.7 SD +/- 5.9 mmol/l (n = 26) to 13.3 SD +/- 4.9 mmol/l (n = 33). Simultaneously both cell membranes hyperpolarize, Vcs from -56.0 SD +/- 4.8 (n = 42) to -62.8 +/- 7.6 (n = 43) and Vcm from -39.6 SD +/- 5.8 (n = 42) to -47.9 +/- 7.6 (n = 43), so that intracellular chloride remains elevated above electrochemical equilibrium at both cell membranes. Reduction or omission of chloride in the lumen perfusate does not affect acCl, suggesting that the luminal cell membrane is virtually tight for chloride ions. Current induced hyperpolarization of the serosal cell membrane potential which simulates the electrical effects of stimulation, does not affect acCl either; however, inhibition of gastric acid secretion by a benzimidazol derivative which is known to block the H+/K+ ATPase prevents the fall in acCl in response to histamine. The same holds if the experimental solutions are gassed with 25% CO2 which does not interfe...Continue Reading


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Mar 1, 1985·Pflügers Archiv : European journal of physiology·T Schettino, S Curci
Jan 1, 1974·The Journal of Membrane Biology·J G SpenneyG Sachs
Sep 1, 1972·Biochimica Et Biophysica Acta·J A Zadunaisky
Apr 1, 1968·Biophysical Journal·C A Canosa, W S Rehm
Dec 1, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T E Machen, T Zeuthen
Oct 1, 1981·Physiological Reviews·W R Loewenstein
Jan 1, 1982·The Journal of Membrane Biology·M J WelshR A Frizzell
May 1, 1984·The American Journal of Physiology·J M Wolosin, J G Forte
Dec 1, 1983·Pflügers Archiv : European journal of physiology·A C CassolaE Frömter
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Related Concepts

Chloride Ion Level
Gastric Acid
Structure of Pyloric Gland
Resting Potentials
Rana esculenta
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