PMID: 9187780Jun 1, 1997Paper

Histamine release during cardiopulmonary bypass in neonates and infants

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
D E Withington, J V Aranda

Abstract

Histamine release has been previously documented in adults and children during cardiopulmonary bypass (CPB). It has not been studied in neonates nor during deep hypothermic circulatory arrest (DHCA). Histamine effects could explain many perioperative complications of congenital cardiac surgery such as dysrhythmias and massive oedema. Therefore, documentation of histamine release in the perioperative period is of clinical importance. The source of histamine can be determined by measurement of tryptase which is released with histamine from mast cells but not basophils. Blood samples for histamine and tryptase were taken before and after specific events eg. cross-clamp removal, during anaesthesia and CPB in 14 infants and seven neonates undergoing complex congenital heart repairs and were analysed by commercial radioimmunoassays. Haemodynamic variables and pre and post-op weights were recorded to look for correlation between pathophysiological events and histamine release. Histamine concentration decreased at the start of bypass (0.69 to 0.38 ng.ml-1 at five minutes, (P < .005). There were no changes associated with DHCA and a small rise with reventilation (P < 0.02). Histamine concentration was lower in neonates than in infants (...Continue Reading

References

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Citations

Jul 4, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Anthony C Chang
Nov 18, 2005·Anaesthesia·K M FayazJ E Hall
Oct 3, 2001·The Journal of Thoracic and Cardiovascular Surgery·K S BandaliC Wittnich
Nov 11, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·R Britt McILwainAkhil Maheshwari
Jan 30, 2008·Anesthesia and Analgesia·Jerrold H Levy, N Franklin Adkinson

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