PMID: 6160921Jul 1, 1980

Histamine release from blood of asthmatics

Clinical Allergy
O CromwellJ Pepys


A group of forty-two steroid-dependent perennial asthmatics was studied over a 13-week period incuding the 8 weeks of a double-blind controlled trial of oral sodium cromoglycate. Given at a dose of 200 mg four times per day the drug provided no significant benefit to the patients when compared with results for those on placebo. Blood from eleven patients consistently failed to release more than 25% of the total cellular histamine when challenged with a range of concentrations of antibody to IgE. All six of the cryptogenic (intrinsic) asthmatics in the trial fell within this group, together with 2/12 asthmatics with negative skin tests but suggestive clinical histories implicating common alergens, and 3/24 extrinsic asthmastics with positive skin prick tests. There was no correlation between drug usage and histamine release in response to challenge with antibody to IgE.


Jan 1, 1975·International Archives of Allergy and Applied Immunology·R P Siraganian, B B Levine
May 1, 1976·The Journal of Clinical Investigation·F Kern, L M LICHTENSTEIN
Jun 1, 1976·The Journal of Allergy and Clinical Immunology·R P Siraganian, M J Brodsky
Aug 1, 1976·The Journal of Investigative Dermatology·B M CzarnetzkiL M LICHTENSTEIN
Jun 1, 1975·Journal of Immunological Methods·R P Siraganian
Dec 1, 1971·Clinical Allergy·E S AssemK M Shaw
Sep 1, 1974·Clinical Allergy·M W GreavesD R Stanworth
Jul 1, 1974·Analytical Biochemistry·S C MarchP Cuatrecasas
May 11, 1968·British Medical Journal·J M Smith, G F Devey
Oct 1, 1971·Toxicology and Applied Pharmacology·G F MossJ S Cox
Feb 15, 1969·British Medical Journal·F E HargreaveJ Pepys

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