Histamine release from the hypothalamus induced by gravity change in rats and space motion sickness

Physiology & Behavior
A UnoT Kubo

Abstract

Freely moving rats were exposed to 2 g hypergravity in an animal centrifuge device to produce motion sickness. Histamine release from the anterior hypothalamus of the rats was measured in vivo with a microdialysis technique. After a 2-h load of 2 g hypergravity, rats ate kaolin. Because pica, eating a nonnutritive substance such as kaolin, is a behavioral index of motion sickness in rats, this finding indicates that the rats suffered from motion sickness. During 2 g hypergravity for 2-h, histamine release from the hypothalamus was transiently increased. In contrast, neither the transient increase of histamine release nor the kaolin consumption were induced by 2 g hypergravity in bilaterally labyrinthectomized rats. Pretreatment with alpha-fluoromethylhistidine, an inhibitor of histamine-synthesizing enzyme, decreased both the basal and hypergravity-induced releases of histamine from the hypothalamus and suppressed the kaolin consumption induced by hypergravity. Taken together, these findings suggest that the vestibular information of changes in gravity activate the histaminergic neuron system, resulting in the development of motion sickness. More prolonged stimulation, a 4-h load of 2 g hypergravity, induced significant increas...Continue Reading

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Citations

Feb 13, 2001·Progress in Neurobiology·R E BrownH L Haas
Nov 28, 2007·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·D V LychakovG A Oganesian
Nov 18, 2014·Journal of Women's Health·April E RoncaMarjorie Jenkins
Apr 15, 2006·The Journal of Physiology·Brahim TighiletMichel Lacour
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Jan 5, 2018·The Journal of Pharmacology and Experimental Therapeutics·Miao-Miao ChenZheng-Lin Jiang
Jul 10, 2018·Scientific Reports·Chanya InprasitChing-Liang Hsieh
Mar 15, 2020·The Journal of Physiological Sciences : JPS·Hironobu MoritaChikara Abe
Jun 3, 2021·International Journal of Molecular Sciences·Weixia ZhongNissar A Darmani

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