PMID: 6167376Jan 1, 1981Paper

Histamine-releasing properties of hydroxy-9-methyl-2-ellipticinium acetate

Cancer Chemotherapy and Pharmacology
A EschalierJ Lavarenne

Abstract

Previous work on Hydroxy-9-methyl-2-ellipticinium acetate indicated a bronchoconstrictor activity which could be partially offset by antagonists of the H1 histamine receptors, and the absence of any direct effect on smooth muscle. OH-9-CH3-2-E at concentrations of 10 micrograms/ml and 500 micrograms/ml produced a moderate and a variable release of histamine when placed in contract with whole human blood and lung fragments, respectively. In addition, at a dose of 3 mg/kg in the guinea pig, pulmonary airway resistance was raised and the blood histamine level lowered. A significant correlation was found between these two effects. These results demonstrate that OH-9-CH3-2-E possesses a histamine-releasing potency which is partly responsible for its bronchial effects, implying that precautions may have to be taken when it is used as a therapeutic agent in sensitive subjects. However, the moderate intensity of this potency has not so far precluded therapeutic use of the preparation.

References

Apr 1, 1972·British Journal of Pharmacology·C AdvenierJ F Giudicelli
Dec 1, 1952·British Journal of Pharmacology and Chemotherapy·A G J EVANSH C STEWART
Jun 29, 1953·The Journal of Physiology·W FELDBERG, J TALESNIK
Sep 1, 1953·The Journal of Physiology·A N SMITH
Feb 1, 1958·The American Journal of Physiology·M O AMDUR, J MEAD

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