Histamine selectively interrupts VE-cadherin adhesion independently of capacitive calcium entry

American Journal of Physiology. Lung Cellular and Molecular Physiology
Michael C WinterD Michael Shasby

Abstract

Histamine is an important agent of innate immunity, transiently increasing the flux of immune-competent molecules from the vascular space to the tissues and then allowing rapid restoration of the integrity of the endothelial barrier. In previous work we found that histamine alters the endothelial barrier by disrupting cell-cell adhesion and identified VE-cadherin as an essential participant in this process. The previous work did not determine whether histamine directly interrupted VE-cadherin adhesion, whether the effects of histamine were selective for cadherin adhesion, or whether capacitive calcium flux across the cell membrane was necessary for the effects of histamine on cell-cell adhesion. In the current work we found that histamine directly interrupts adhesion of L cells expressing the type 1 histamine (H1) receptor and VE-cadherin to a VE-cadherin-Fc fusion protein. In contrast, integrin-mediated adhesion to fibronectin of the same L cells expressing the H1 receptor was not affected by histamine, demonstrating that the effects of histamine are selective for cadherin adhesion. Some of the effects of many edemagenic agonists on endothelium are dependent on the capacitive flux of calcium across the endothelial cell membran...Continue Reading

References

Dec 1, 1992·The American Journal of Physiology·M R CarsonD M Shasby
Apr 1, 1992·The American Journal of Physiology·N Z Wu, A L Baldwin
Oct 1, 1989·The American Journal of Physiology·M R CarsonD M Shasby
Jan 1, 1986·Journal of Applied Physiology·D M Shasby, S S Shasby
Jun 15, 1994·Biochemical and Biophysical Research Communications·H FukuiS Ito
Dec 1, 1993·The American Journal of Physiology·R SheldonD M Shasby
Feb 15, 1996·The Journal of Clinical Investigation·A B MoyD M Shasby
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·M CoradaE Dejana
Nov 24, 1999·The American Journal of Physiology·M C WinterD M Shasby
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·A B MoyD M Shasby
Sep 21, 2001·The Journal of Cell Biology·S WuT Stevens
May 11, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·D Michael ShasbyMichael C Winter
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·G MAJNO, G E PALADE

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Citations

Dec 17, 2009·Nature Structural & Molecular Biology·Quansheng ZhouXiang-Lei Yang
Oct 17, 2012·Cardiovascular Research·Margreet R de VriesPaul H A Quax
Dec 17, 2009·Disease Models & Mechanisms·Angela J Glading, Mark H Ginsberg
Jan 21, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Perttu Johannes LindsbergMarja-Liisa Karjalainen-Lindsberg
Sep 1, 2007·Journal of Cellular and Molecular Medicine·Ken A LindstedtPetri T Kovanen
Oct 19, 2006·Coronary Artery Disease·Mikko I MäyränpääPetri T Kovanen
May 23, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael C WinterD Michael Shasby
Nov 7, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·D Michael Shasby
Dec 18, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael C WinterD Michael Shasby
May 5, 2009·Annals of Medicine·Daniel StrbianPerttu J Lindsberg

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