PMID: 2124421Dec 1, 1990Paper

Histamine stimulates proliferation of airway smooth muscle and induces c-fos expression

The American Journal of Physiology
R A PanettieriM I Kotlikoff

Abstract

Although chronic severe asthma is characterized by increased smooth muscle mass in the airways, the physiological stimuli that promote airway smooth muscle (ASM) proliferation (hyperplasia) or increase ASM protein expression (hypertrophy) are unknown. We examined the effects of histamine, an autocoid associated with airway hyperresponsiveness, on protein synthesis, myosin heavy chain expression, and cell proliferation in cultured canine ASM cells. In confluent ASM cells, histamine significantly increased incorporation of [35S]-methionine in protein. Maintenance of the proportion of smooth muscle-specific myosin heavy chain to total myosin heavy chain suggested a nonspecific increase in contractile protein expression. DNA synthesis, as measured by [3H]thymidine incorporation, was significantly increased by histamine in a concentration-dependent manner. Cell proliferation paralleled [3H]thymidine incorporation; histamine significantly increased cell numbers at 24 and 48 h of stimulation. Because growth of mesenchymal-derived cells is associated with transcription of c-fos mRNA, we examined whether histamine altered expression of this proto-oncogene. Histamine-treated cells showed marked increases in expressions of steady-state c-...Continue Reading

Citations

Aug 18, 2001·Journal of Applied Physiology·A J Ammit, R A Panettieri
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·V P KrymskayaR A Panettieri
Jan 21, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M JutelC A Akdis
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·R A Panettieri
Nov 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·S PageC L Armour
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elena A GoncharovaVera P Krymskaya
Feb 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yassine AmraniReynold A Panettieri
Aug 20, 2004·American Journal of Physiology. Cell Physiology·Melissa WahlChi-Ming Hai
Oct 15, 2008·Annual Review of Physiology·Omar Tliba, Reynold A Panettieri
Dec 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D KaurC Brightling
Mar 4, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Marina C Simeone-PenneyAmy R Simon
Aug 18, 2001·Journal of Applied Physiology·P BergerA F Walls
Nov 14, 2006·Journal of Pharmacological Sciences·Kazuto MatsuyamaHiroyuki Fukui
Aug 19, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nadia A HasaneenHussein D Foda
Jan 12, 2013·Journal of Applied Physiology·Diana C Doeing, Julian Solway
Oct 1, 2003·Respiratory Physiology & Neurobiology·Limei Zhou, Marc B Hershenson

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