PMID: 6165750Jul 1, 1981Paper

Histamine suppression of in vivo eosinophil accumulation and histamine release in human allergic reactions

The Journal of Allergy and Clinical Immunology
S TingE H Dunsky

Abstract

Although it has been shown that histamine inhibits antigen-induced in vitro histamine release from basophils, it is unclear whether histamine inhibits in vivo mediator release in human allergic reactions. We report effects of exogenous histamine on histamine release and inflammatory cell responses in antigen-challenged skin sites in eight ragweed-sensitive individuals. Four heat-suction blisters in each subject were unroofed, and a collection chamber was appended to each blister base. Chamber A contained 1000 PNU/ml ragweed extract; chamber B contained buffered saline (control fluid); chamber C contained 1000 PNU/ml ragweed and 50 ng (5 x 10(-7) M) of histamine; and chamber D contained histamine alone (50 ng). Comparative analyses of chamber histamine levels in individual subjects showed that (1) histamine levels in chamber A were significantly greater than those in chamber B (p less than 0.01) and that histamine levels in chamber C were not significantly different than those in chamber D (p less than 0.5). Likewise, comparison of eosinophils attaching to membrane filters appended to the chamber bases for 2 hr showed that there were significantly more eosinophils in chamber A than in chamber B (p less than 0.01) and that there ...Continue Reading

References

Dec 1, 1975·The Journal of Experimental Medicine·R A ClarkA P Kaplan
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Jun 1, 1978·The Journal of Allergy and Clinical Immunology·A P KaplanS I Katz
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Citations

Mar 12, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·J-M MalinovskyB Plaud
Jul 1, 1988·The Journal of Allergy and Clinical Immunology·M M PienkowskiL M Lichtenstein
Jul 28, 2004·The Annals of Otology, Rhinology, and Laryngology·Muneo NakayaKenji Kondo
Jul 1, 1987·Clinical Allergy·R FadelE Henocq
Sep 1, 1988·Clinical Allergy·B Zweiman

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