Histaminergic afferent system in the cerebellum: structure and function

Cerebellum & Ataxias
Bin LiJian-Jun Wang

Abstract

Histaminergic afferent system of the cerebellum, having been considered as an essential component of the direct hypothalamocerebellar circuits, originates from the tuberomammillary nucleus in the hypothalamus. Unlike the mossy fibers and climbing fibers, the histaminergic afferent fibers, a third type of cerebellar afferents, extend fine varicose fibers throughout the cerebellar cortex and nuclei. Histamine receptors, belonging to the family of G protein-coupled receptors, are widely present in the cerebellum. Through these histamine receptors, histamine directly excites Purkinje cells and granule cells in the cerebellar cortex, as well as the cerebellar nuclear neurons. Therefore, the histaminergic afferents parallelly modulate these dominant components in the cerebellar circuitry and consequently influence the final output of the cerebellum. In this way, the histaminergic afferent system actively participates in the cerebellum-mediated motor balance and coordination and nonsomatic functions. Accordingly, histaminergic reagents may become potential drugs for clinical treatment of cerebellar ataxia and other cerebellar disease. On the other hand, considering the hypothalamus is a high regulatory center for autonomic and viscera...Continue Reading

References

Jan 1, 1991·Physiological Reviews·J C SchwartzM Ruat
Jul 1, 1989·Neurochemical Research·J RodriguezA J Patel
Jan 1, 1989·Neuroscience·P PanulaM S Airaksinen
Aug 15, 1989·The Journal of Comparative Neurology·M S AiraksinenP Panula
Jul 15, 1988·The Journal of Comparative Neurology·N InagakiH Wada
Jan 21, 1986·European Journal of Pharmacology·M KornerJ C Schwartz
Jan 1, 1973·Progress in Neurobiology·J R Bloedel
Jan 1, 1984·The Japanese Journal of Physiology·M Ito
Jul 15, 1982·Brain Research·J E TaylorE Richelson
Sep 17, 1993·Neuroscience Letters·P PanulaE Kotilainen
Sep 1, 1993·Journal of Biochemistry·Y HorioH Fukui
Jun 1, 1996·The European Journal of Neuroscience·S KirischukH Kettenmann
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·I InoueT Watanabe
Jan 1, 1997·International Review of Neurobiology·D E HainesE F McDonald
Apr 29, 1998·Naunyn-Schmiedeberg's Archives of Pharmacology·J TimmE Schlicker
Jul 10, 1999·Journal of Physiology, Paris·W C LiJ J Wang
Jan 19, 2000·Trends in Pharmacological Sciences·R LeursH Timmerman
Mar 18, 2000·Neuroscience Research·L TianJ J Wang
Dec 19, 2000·Biochemical and Biophysical Research Communications·T NakamuraK Tanaka
Feb 13, 2001·Progress in Neurobiology·R E BrownH L Haas
Feb 17, 2001·Molecular Pharmacology·T NguyenB F O'Dowd

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Citations

Dec 15, 2017·The Journal of Comparative Neurology·Vincenzo BenagianoGlauco Ambrosi
Nov 16, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Anna RizziVincenzo Benagiano
May 5, 2016·Cerebellum & Ataxias·Xiao-Yang ZhangJing-Ning Zhu
Jul 21, 2020·World Journal of Gastroenterology : WJG·Zhi Yu
Oct 15, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cara L GreenJohn R Speakman

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BETA
deamination

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