PMID: 9662739Jul 15, 1998Paper

Histaminergic and noradrenergic control of cyclic AMP formation in the pineal gland and cerebral cortex of three avian species: cock, duck, and goose

Polish Journal of Pharmacology
J Z NowakJ B Zawilska

Abstract

The goal of the present study was to examine the effects of forskolin (FOR), histamine (HA), L-noradrenaline (NA), isoprenaline (ISO) and dopamine (DA) on cyclic AMP formation in whole pineal glands and cerebral cortical slices of cock, duck and goose. HA (100 muM) and FOR (10 muM) potently increased cyclic AMP production in the pineal glands of all studied avian species, showing a synergistic interaction when applied together. HA at the dose of 1 mM significantly stimulated adenylyl cyclase activity in the membrane preparations of cock pineal glands while lower concentrations were ineffective. HA markedly enhanced cyclic AMP formation in cerebral cortex of cock (an effect being potentiated for FOR), but did not affect the nucleotide production in this brain structure of duck and goose. DA (100 muM) had no effect, NA (100 muM) only moderately (5-22% increased, where ISO (10muM) significantly (by 50-90%) enhanced cyclic AM_ synthesis in avian cerebral cortex. Propranolol (1 muM) antagonized all these effects, while preincubation with yohimbine and prazosin significantly enhanced NA action in cortical slices of duck and goose.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.