Abstract
The insular cortex (IC) processes multimodal sensory information including gustatory, visceral, nociceptive, and thermal sensation, and is considered to play a role in the regulation of homeostasis. The IC receives dense histaminergic projection from the tuberomamillary nucleus in the hypothalamus, and recent studies have demonstrated that the blockage of histaminergic receptors impairs physiological functions in the IC. However, little is known about the effects of histamine on the electrophysiological properties of the IC. To explore the effects of histamine on the subthreshold responses and action potential properties in the IC, intracellular recording with a sharp glass electrode was obtained from IC pyramidal cells in cortical slice preparations. Application of histamine (30 μM) increased the frequency of repetitive spike firing in response to a long depolarizing current pulse injection; accompanied by an increase in input resistance. The frequency of repetitive spike firing was estimated by the slope of the frequency-current (f/I) curve. Histamine caused an increase from 23.3±2.3 Hz/nA to 40.3±4.3 Hz/nA. The histamine-induced facilitation of repetitive spike firing was blocked by pre-application of 50 μM cimetidine, an H(...Continue Reading
References
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D A McCormick, A Williamson
Dec 15, 1994·Behavioural Brain Research·T YamamotoN Sakai
Sep 1, 1993·Cerebral Cortex·D A McCormickJ Huguenard
Jan 25, 1996·European Journal of Pharmacology·E A Clark, S J Hill
Jun 11, 1999·Neuroscience·H Mitoma, S Konishi
Feb 13, 2001·Progress in Neurobiology·R E BrownH L Haas
Sep 5, 2002·Neuroscience·C PillotJ-M Arrang
Oct 7, 2004·Molecular Pharmacology·Anna TorrentJordí Ortiz
Jun 2, 2006·Journal of Neurophysiology·Fu-Wen ZhouFu-Ming Zhou
Feb 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Riccardo AccollaAlan Carleton
May 5, 2007·Neuroscience·M Kobayashi
Dec 7, 2007·Neuroscience Letters·Masayuki KobayashiNoriaki Koshikawa
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Sep 9, 2009·Neuroscience·D Moreno-DelgadoJ Ortiz
Oct 15, 2009·Neurobiology of Learning and Memory·Liliana Purón-SierraMaría Isabel Miranda
Dec 4, 2009·Synapse·Masayuki KobayashiNoriaki Koshikawa
Aug 10, 2010·Neuroscience·H TakeiM Kobayashi
Citations
Nov 25, 2017·Frontiers in Neural Circuits·Hiroki TakeiMasayuki Kobayashi
Nov 7, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jennifer M SpaethlingJames H Eberwine
Mar 27, 2020·Cellular and Molecular Neurobiology·Tamara CoslovichGiuliano Taccola