PMID: 7543795Apr 1, 1995Paper

Histaminergic nerves demonstrated in the skin. A new direct mode of neurogenic inflammation?

Experimental Dermatology
O JohanssonM Hilliges

Abstract

An intradermal administration of histamine into human skin results in a local erythema, edema and often also the sensations of itch and/or pain. These effects have classically been attributed to the presence of histamine-containing mast cells. However, in the present investigation, we report the observation of histamine-immunoreactive nerves in the skin of Sprague-Dawley rats using a new and highly sensitive immunohistochemical approach. These data suggest a more direct route of cutaneous histamine effects, mediated exclusively by the peripheral nervous system. The findings could also give a new basis for explaining histamine-related issues, such as itch.

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Citations

Jul 17, 2008·Expert Opinion on Pharmacotherapy·Robert H Demling
Sep 27, 2003·Dermatologic Therapy·Robert A Norman
Oct 21, 2000·Endocrine Reviews·A Slominski, J Wortsman

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