PMID: 2484226Oct 1, 1989Paper

Histidine supplement and Zn status in Swiss random mice

Biological Trace Element Research
J P Van WouweC J Van den Hamer

Abstract

The influence of either histidine supplement or nutritional Zn deficiency on growth and the organ and tissue Zn content of mice during a 21-d period was compared with a control group. When the histidine intake was increased from 5 to 9 mumol/g body wt/d we noted increased body weight and higher Zn concentrations in liver, pancreas, spleen, and muscle. As a result, the estimated whole body Zn mass increased. This was explained by enhanced utilization of dietary Zn. These results differed from those seen in Zn deficient animals (fed 5 nmol Zn/g body wt/d instead of 29). Dietary Zn deficiency was characterized by anorexia and growth retardation, lower Zn concentrations in pancreas, muscle, bone, tail, and plasma, plus higher Zn concentrations in spleen and fur. As a result, the estimated total body Zn mass was 20% lower than in the control animals, despite a two-to threefold increase in utilization of dietary Zn. These results are discussed in view of the available literature. It is concluded that in humans and in animals both the absorption and the excretion of Zn may be increased by histidine. Below a certain dose the former will prevail, viz., a situation of increased utilization exists, preventing the development of Zn deficie...Continue Reading

References

May 1, 1979·The American Journal of Clinical Nutrition·P J Schechter, N J Prakash
Apr 1, 1977·The American Journal of Clinical Nutrition·R M Freeman, P R Taylor
Jul 1, 1988·Biological Trace Element Research·J Wensink, C J Van den Hamer
Nov 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·K E de HaanC J van den Hamer
Jan 1, 1981·The American Journal of Clinical Nutrition·A A GeliebterT B Van Itallie
Apr 1, 1981·The Journal of Nutrition·P W HarveyK G Allen

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Citations

Aug 1, 1992·Journal of Cellular Physiology·R D RaffanielloR A Wapnir
Jul 1, 1993·Biological Trace Element Research·J De KokH T Wolterbeek
Aug 1, 1994·Biological Trace Element Research·J P Van Wouwe, J J Uijlenbroek
Jan 1, 1989·Biological Trace Element Research·G J Van den BergA C Beynen
Mar 1, 1990·Biological Trace Element Research·J P Van WouweC J Van den Hamer

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