Histiocytic differentiation in acute monocytic leukemia

Ultrastructural Pathology
Yong-xin RuJian-xiang Wang

Abstract

Myeloid histocytes of dendritic cells (DCs), Langerhans cells (LCs), and macrophages in varied tissues, as leukemic blasts in acute monoblastic and monocytic leukemia (AML-M5a and M5b), are derived from monocyte progenitors in bone marrow. Based on DC induction from hematopoietic stem cells, myeloid progenitors, and monocytes, and occasional expressions of histocyte-related antigens (HRAs) in M5, we presume some M5 cases share histiocytic phenotypes originally. To clarify the conception, 93 M5 cases were tested with antibodies for HRAs, CD1a, CD163, S100, fascin, and langerin by immunostaining, and their morphologic characteristics were studied by light and transmission electron microscopy. The study revealed that 23 M5 cases were positive for two or more kinds of HRAs and shared a serial of histocytic immunophenotype and morphologic features, which were closely associated with M5b subtype and expression of CD14 in M5.

References

Nov 10, 2001·Nature Immunology·A T LarreginaL D Falo
Feb 8, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jeffrey A VosNadine S Aguilera
Jul 20, 2007·American Journal of Hematology·Sebastien KairouzImad A Tabbara
Jun 11, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Christine GarciaKaaren K Reichard
Mar 11, 2009·Ultrastructural Pathology·Yong-Xin RuJian-Xiang Wang
Mar 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carl E AllenKenneth L McClain
May 5, 2010·Journal of Clinical Pathology·Tomohiko OriiMitsunori Yamakawa

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Citations

Oct 20, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Dimas Suárez-Vilela, Francisco M Izquierdo
Sep 22, 2020·International Journal of Hematology·Bing Liu, Ting Li

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