Histiocytic disorders: recent insights into pathophysiology and practical guidelines

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Alexandra FilipovichAlexei A Grom

Abstract

The Histiocytoses are defined as non-malignant disorders due to abnormal accumulation and behavior of cells of the mononuclear phagocytic system. The best known histiocytoses, Langerhans cell histiocytosis (LCH), and hemophagocytic lymphohistiocytosis (HLH), each with an estimated incidence of 1/50,000 to 1/150,000, are sufficiently "common," complex and costly, to constitute an important problem in medical practice. At the same time, LCH, HLH and an array of other and more rare histiocytoses are sufficiently uncommon that most physicians lack the experience to diagnose, let alone care for patients with these conditions. The pathophysiology of most of the histiocytoses is unknown and, in the case of the widely-disseminated and potentially fatal forms, treatments to date have been variably effective and sometimes highly toxic. MAS has been reported to occur in association with almost any rheumatic disease, it is by far most common in the systemic form of Juvenile Idiopthic Arthritis (SoJIA). It is now recognized that MAS bears a close resemblance to Hemophagocytic Lymphohistiocytosis or HLH, and MAS is recognized as the major fatal complication of soJIA.

References

Oct 26, 1989·The New England Journal of Medicine·D B DungerJ Pritchard
Dec 1, 1983·The Journal of Pediatrics·E D SilvermanT Shafai
Oct 23, 2001·Archives of Disease in Childhood·S SawhneyK J Murray
Sep 25, 2004·Pediatric Blood & Cancer·Jorge BraierJulio Goldberg
Sep 25, 2004·Pediatric Blood & Cancer·Michael B JordanRonald Jaffe
May 27, 2005·British Journal of Haematology·Annacarin HorneUNKNOWN Histiocyte Society
Jul 28, 2005·Pediatric Blood & Cancer·N GroisUNKNOWN DALHX- and LCH I and II Study Committee
Nov 18, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F BernardJ Donadieu
Feb 28, 2006·Bone Marrow Transplantation·A SreedharanR P Nelson
Aug 29, 2006·Pediatric Blood & Cancer·Jan-Inge HenterGritta Janka
Jun 24, 2008·The Journal of Pediatrics·Martha WnorowskiNicole Grois

❮ Previous
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Citations

Aug 8, 2012·Infection and Immunity·Melissa W McCoyCorrella S Detweiler
Dec 14, 2011·Hematology·Sheila Weitzman
Jun 30, 2014·Best Practice & Research. Clinical Rheumatology·Grant S Schulert, Alexei A Grom
Feb 11, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Iwona MalinowskaBarbara Nasiłowska-Adamska
May 6, 2015·Pathology·Dina El DemellawyAhmed Nasr
Feb 24, 2016·Journal of Clinical and Experimental Hepatology·Sahaj Rathi, Radha K Dhiman
Dec 23, 2015·Case Reports in Radiology·Takashi Takahashi, Jeffrey Rykken
May 24, 2011·Transfusion·Melissa R GeorgeEric M Behling
Apr 23, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Sunyoung LeeJohn O Mascarenhas
Oct 14, 2014·Hemodialysis International·Sindhura L Koulmane LaxminarayanaBrahmaiah Chari
Jun 14, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ariel DroriRifaat Safadi
Jul 12, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Utpal PajvaniMartin M Grajower
Apr 15, 2015·BMJ Case Reports·Yee Man Tracy HuiNichola Cooper
Jul 14, 2012·Blood·Rania Al HawasSidney W Whiteheart
Jun 4, 2010·Blood·Gayane Badalian-VeryBarrett J Rollins
Jun 5, 2015·Journal of Clinical and Experimental Hepatology·Anil C Anand, Hitendra K Garg
Feb 5, 2016·The American Journal of Dermatopathology·Eliza NotaroMichi M Shinohara
Jun 9, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elizabeth JunaidCatherine Quinlan
Jun 22, 2016·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Jens VikseTore Grimstad
Sep 8, 2016·Medicine·Stéphane MathisJean-Philippe Neau
Aug 9, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·I RomiopoulosE Roilides
Oct 18, 2016·Internal Medicine·Yukimi Otsuka, Yasushi Inoue
Mar 3, 2012·International Archives of Allergy and Immunology·UNKNOWN WHO Collaborating Center for Asthma and RhinitisT Zuberbier
Nov 18, 2016·Rheumatology International·L García-MontoyaE Naredo
Mar 24, 2017·Journal of Clinical and Experimental Hematopathology : JCEH·Daniel MarkoMichel R Nasr
Jan 7, 2017·Journal of Pediatric Hematology/oncology·Zeliha HaytogluAyse Erbay
Apr 16, 2016·Clinical Medicine Insights. Pediatrics·Ghaleb ElyamanyFahad Alabbas
Jan 17, 2017·Pulmonary Circulation·Julius KoifmanJohn Thenganatt
Jun 7, 2018·JAMA Dermatology·Dylan E LeeJoan Guitart
Feb 13, 2018·International Journal of STD & AIDS·Nisha LoganantharajShane Sanne
Dec 5, 2017·Journal of Pediatric Hematology/oncology·Kai-Qian KamRajat Bhattacharyya
Feb 13, 2018·Journal of Pediatric Hematology/oncology·Aida ZečkanovićMarko Kavčič
Nov 28, 2018·American Journal of Hematology·Chelsea Kennedy-SnodgrassMarc Braunstein
Apr 10, 2019·The Journal of International Medical Research·Xiaoyang YangPeilong Huang
Jun 4, 2019·AACN Advanced Critical Care·Janice SkinnerBrenda K Shelton

❮ Previous
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