Histiocytic osteolysis secondary to hyperbilirubinaemia: a case report

Journal of Orthopaedic Surgery
T NakamuraA Uchida

Abstract

A 6-year-old boy with Alagille syndrome, characterised by marked hyperbilirubinaemia, presented with malunion of a pathological fracture of the femur with local bone atrophy and insufficient callus formation. During corrective osteotomy, it was noted that the femur was stained dark green, suggestive of bilirubin deposition. Histology of the resected bone revealed the presence of many histiocytes and osteoclast-like multinucleate giant cells containing bilirubin particles in the cytoplasm causing bone resorption. These findings suggest that bilirubin may activate macrophages to form osteoclast-like multinucleate giant cells, resulting in histiocytic osteolysis.

References

Mar 4, 1998·Paediatric Anaesthesia·D K ChoudhryD A Piccoli
Jan 10, 2002·European Journal of Gastroenterology & Hepatology·Sif OrmarsdóttirLars Lööf
Feb 8, 2003·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jirí GalloRudolf Ditmar
Sep 29, 2004·Diagnostic Cytopathology·Anil V ParwaniSyed Z Ali
Apr 26, 2005·Transplantation Proceedings·G MaldiniM Colledan

❮ Previous
Next ❯

Citations

May 11, 2010·Journal of Pediatric Gastroenterology and Nutrition·Christina B BalesKathleen M Loomes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alagille Syndrome

Alagille syndrome is a multi-system genetic disorder that can affect the liver, heart, and other parts of the body. It’s characterization includes heart problems, liver damage, jaundice, and xanthomas. Here is the latest research.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
I ItonagaN A Athanasou
Journal of Inherited Metabolic Disease
P IpP T Cheung
© 2022 Meta ULC. All rights reserved