PMID: 9537592Apr 16, 1998Paper

Histo-blood group A/B antigen deletion/reduction vs. continuous expression in human tumor cells as correlated with their malignancy

International Journal of Cancer. Journal International Du Cancer
D IchikawaS Hakomori

Abstract

Deletion or reduction of histo-blood group A or B antigen in tumors of A or B individuals is clearly correlated with the degree of malignancy and metastatic potential in many types of human cancer. Haptotactic motility of A+H- or B+H- colonic or gastric tumor cell lines produced by transfection of A or B gene was significantly lower than that of parental A-H+ or B-H+ cells. This is ascribable to reduced function of alpha3 or alpha6/beta1 integrin receptor as we have recently shown. However, phenotypic changes resulting from gene transfection may not reflect physiological states associated with deletion or reduction vs. continuous expression of A or B antigen in tumors. We now describe the separation and phenotype characterization of A- cells from A+ tumor cell lines derived originally from colonic tumors of patients with histo-blood group A. A+ and A- populations were detected in originally A+ tumor cell lines SW480 and HT29. A- separated from A+ populations isolated from SW480 and HT29 were characterized by greatly enhanced haptotactic motility associated with reduced or deleted A expression at alpha3, alpha6, and beta1 integrin receptors which control cell motility. Nevertheless, expression of integrin receptors at the surfac...Continue Reading

Citations

Sep 28, 1999·The Laryngoscope·X XieM A Bryne
Dec 14, 2011·Archivos de bronconeumología·Pablo León-AtanceEmilio Alvarez-Fernández
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Qiwen BenZhaoshen Li
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Arseniy E Yuzhalin, Anton G Kutikhin
Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Erik Dabelsteen
Dec 24, 2004·Journal of Dental Research·E Dabelsteen, S Gao
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Yasemin Benderli CihanArzu Oguz
Jun 30, 2019·International Journal of Environmental Research and Public Health·Dijana CelićTajana Borlinić

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