PMID: 6159716Jan 1, 1980Paper

Histochemical analysis of senile plaque amyloid and amyloid angiopathy

Virchows Archiv. A, Pathological Anatomy and Histology
A ProbstJ Ulrich

Abstract

Histochemical methods were used to obtain information on the chemical constituents of brain amyloid in senile dementia of the Alzheimer type. The staining properties of brain amyloid (senile plaque and amyloid angiopathy) were compared with those of extraneural amyloidosis and endocrine amyloid. We found no histochemical differences between amyloid in senile plaques and in amyloid angiopathy. The content of aromatic amino acids was higher in amyloid of plaques and in amyloid angiopathy than in endocrine amyloid. Furthermore, we found persistent birefringence and affinity of brain amyloid for Congo red after exposure to potassium permanganate, suggesting that AA amyloid is not a major constituent of cerebral amyloid.

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Citations

Jan 1, 1988·Acta Neuropathologica·J M Powers, J T Skeen
Feb 3, 1986·Klinische Wochenschrift·J UlrichJ Kahn
Feb 16, 2000·Neurobiology of Aging·W C BenzingK R Brunden
May 1, 1983·Acta Pathologica Japonica·S SuminoS Murao
Jan 1, 1993·Progress in Histochemistry and Cytochemistry·J Ulrich
May 13, 2003·Chembiochem : a European Journal of Chemical Biology·Boris Schmidt
Nov 1, 1983·Stroke; a Journal of Cerebral Circulation·J J Gilbert, H V Vinters
Mar 1, 1987·Stroke; a Journal of Cerebral Circulation·H V Vinters
May 30, 2014·Reviews in the Neurosciences·Juliette A KampWilleke M C van Roon-Mom
Jan 1, 1982·Acta Neuropathologica·J M PowersC J Rosenthal
Nov 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·H V Vinters, W M Pardridge
Aug 1, 1985·Journal of the Neurological Sciences·I ElovaaraT Erkinjuntti

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