PMID: 429206Feb 21, 1979Paper

Histochemical and atomic absorption demonstration of trace metal mobilization in the central nervous system and liver of the rat

Histochemistry
A FerkeP Kása

Abstract

Histochemical and atomic absorption spectrophotometric analysis of trace metal mobilization caused by the action of ethanol in the central nervous system (CNS) and liver of the rat is described. Histochemically it has been shown that in all neurons examined (motoneurons, pyramidal and Purkinje cells) the trace metals (mainly Zn2+ and Cu2+) are mobilized. Most of the stained materials disappear from the perikaryon of the Purkinje cells, while in both the motoneurons and the pyramidal cells the trace metals are displaced from the perikaryon into the axon and axon hillock. At the same time, some of the glia cells display a high metal content. Quantitative determination of the Zn2+ and Cu2+ by means of atomic absorption spectrophotometry reveals that after 2 hours ethanol treatment both the Zn2+ and the Cu2+ levels are decreased in the archicerebellar cortex, while after 4 hours the Zn2+ levels are increased in the cerebrum and the spinal cord. The present observations on the histochemical localization and the contents of zinc and copper in different parts of the CNS and liver reveal the important role of the effect of ethanol on the trace metal mobilization.

References

Jul 1, 1976·Journal of Neurochemistry·R W Guynn
Apr 1, 1977·Biochemical Pharmacology·I WajdaJ P Hudick
Nov 15, 1977·Biochemical Pharmacology·B GruberS Tewari
Mar 1, 1977·Biochemical Pharmacology·C Dippel, J H Ferguson
May 1, 1974·The Journal of Pharmacy and Pharmacology·F H Schneider
Jan 1, 1973·Canadian Journal of Biochemistry·J DonaldsonA Barbeau
Jun 1, 1972·Journal of Neurochemistry·I L Crawford, J D Connor
Jul 1, 1968·Journal of Neurochemistry·K H Hu, R L Friede
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

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