Jul 1, 1989

Histochemical and immunohistochemical evidence of glandular differentiation in thymic carcinoma

Acta Pathologica Japonica
Y MatsunoY Shimosato


Eighteen cases of primary thymic carcinoma were reviewed from the viewpoint of glandular differentiation. Squamous differentiation was evident in 14 cases (83%). Immunohistochemical study revealed secretory component (SC)-positive carcinoma cells in 12 cases (67%), most of which were also associated with squamous differentiation. Three of these 12 cases contained areas with a definite glandular or microcystic structure with occasional epithelial mucin, and were diagnosed as adenosquamous carcinoma. Review of patients' medical records revealed that thymic carcinomas with a glandular element were more often resectable at surgery, and had a much better prognosis than those without a glandular element. However, further study on larger number of cases is necessary to confirm this relationship. Because SC-positive epithelial cells do exist in the non-neoplastic thymus, the presence of a glandular component suggests another direction of morphological and/or functional differentiation of thymic carcinoma cells in addition to the well-known squamous differentiation.

  • References14
  • Citations12


  • References14
  • Citations12


Mentioned in this Paper

Adenosquamous Carcinoma
Mucin-1 protein
Neoplasm of Uncertain or Unknown Behavior of Thymus
Squamous Transitional Epithelial Cell Count
Disease of Thymus Gland
Tumor Markers
Thymic Tissue
Cell Differentiation Process

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